ul_2795----
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PPBD protein
Gene name GRAP2( Description: GRB2-related adaptor protein 2. )
Synonyms Adapter protein GRID; GADS; GADS protein; GRAP-2; GRB-2-like protein; GRB2L; GRBLG; GRBX; GRID; GRPL; GrbX; Grf-40; Grf40; Grf40 adapter protein; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; Mona; P38; SH3-SH2
GO annotations GO_component: cytoplasm [PMID 9878555]
GO_function:protein binding [PMID 12359715]; SH3/SH2 adaptor activity [PMID 9878555]
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 9878555]; cell-cell signaling [PMID 9878555]; intracellular signaling cascade; Ras protein signal transduction [PMID 9878555]
RefSeq accession NP_004801
SwissProt accession O75791
Substrate protein
Gene name Csf1r( Description: colony stimulating factor 1 receptor. )
Synonyms AI323359; CD115; CSF-1R; Csfmr; Fim-2; Fms; M-CSFR
GO annotations GO_component: intracellular; membrane
GO_function:ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
GO_process: cellular physiological process; protein amino acid phosphorylation; regulation of progression through cell cycle; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_031805
SwissProt accession
GO Pathway:
GO:0007165     signal transduction
Sequence:(RefSeq accession:NP_031805; substrate region highlighted if known)
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MELGPPLVLL LATVWHGQGA PVIEPSGPEL VVEPGETVTL RCVSNGSVEW DGPISPYWTL
DPESPGSTLT TRNATFKNTG TYRCTELEDP MAGSTTIHLY VKDPAHSWNL LAQEVTVVEG
QEAVLPCLIT DPALKDSVSL MREGGRQVLR KTVYFFSPWR GFIIRKAKVL DSNTYVCKTM
VNGRESTSTG IWLKVNRVHP EPPQIKLEPS KLVRIRGEAA QIVCSATNAE VGFNVILKRG
DTKLEIPLNS DFQDNYYKKV RALSLNAVDF QDAGIYSCVA SNDVGTRTAT MNFQVVESAY
LNLTSEQSLL QEVSVGDSLI LTVHADAYPS IQHYNWTYLG PFFEDQRKLE FITQRAIYRY
TFKLFLNRVK ASEAGQYFLM AQNKAGWNNL TFELTLRYPP EVSVTWMPVN GSDVLFCDVS
GYPQPSVTWM ECRGHTDRCD EAQALQVWND THPEVLSQKP FDKVIIQSQL PIGTLKHNMT
YFCKTHNSVG NSSQYFRAVS LGQSKQLPDE SLFTPVVVAC MSVMSLLVLL LLLLLYKYKQ
KPKYQVRWKI IERYEGNSYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF
GLGKEDAVLK VAVKMLKSTA HADEKEALMS ELKIMSHLGQ HENIVNLLGA CTHGGPVLVI
TEYCCYGDLL NFLRRKAEAM LGPSLSPGQD SEGDSSYKNI HLEKKYVRRD SGFSSQGVDT
YVEMRPVSTS SSDSFFKQDL DKEASRPLEL WDLLHFSSQV AQGMAFLASK NCIHRDVAAR
NVLLTSGHVA KIGDFGLARD IMNDSNYVVK GNVLPVKWMA PESIFDCVYT VQSDVWSYGI
LLWEIFSLGL NPYPGILVNN KFYKLVKDGY QMAQPVFAPK NIYSIMQSCW DLEPTRRPTF
QQICFLLQEQ ARLERRDQDY ANLPSSGGSS GSDSGGGSSG GSSSEPEEES SSEHLACCEP
GDIAQPLLQP NNYQFC
Records:
Category Evidence Reference
A Mutagenesis Bourgin C, Bourette R, Mouchiroud G, Arnaud S., Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation, [11034310]
End of Record Details