ul_2797----
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PPBD protein
Gene name GRAP2( Description: GRB2-related adaptor protein 2. )
Synonyms Adapter protein GRID; GADS; GADS protein; GRAP-2; GRB-2-like protein; GRB2L; GRBLG; GRBX; GRID; GRPL; GrbX; Grf-40; Grf40; Grf40 adapter protein; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; Mona; P38; SH3-SH2
GO annotations GO_component: cytoplasm [PMID 9878555]
GO_function:protein binding [PMID 12359715]; SH3/SH2 adaptor activity [PMID 9878555]
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 9878555]; cell-cell signaling [PMID 9878555]; intracellular signaling cascade; Ras protein signal transduction [PMID 9878555]
RefSeq accession NP_004801
SwissProt accession O75791
Substrate protein
Gene name LAX1( Description: lymphocyte transmembrane adaptor 1. )
Synonyms FLJ20340; LAX; Linker for activation of X cells; Membrane-associated adapter protein LAX
GO annotations GO_component: integral to membrane [PMID 12359715]; lipid raft [PMID 12359715]; membrane
GO_function:protein binding [PMID 12359715]; protein kinase binding [PMID 12359715]; SH2 domain binding [PMID 12359715]
GO_process: B cell activation [PMID 12359715]; immune response [PMID 12359715]; inactivation of MAPK activity [PMID 12359715]; intracellular signaling cascade [PMID 12359715]; negative regulation of T cell activation [PMID 12359715]
RefSeq accession NP_060243
SwissProt accession Q8IWV1
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_060243; substrate region highlighted if known)
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MDGVTPTLST IRGRTLESST LHVTPRSLDR NKDQITNIFS GFAGLLAILL VVAVFCILWN
WNKRKKRQVP YLRVTVMPLL TLPQTRQRAK NIYDILPWRQ EDLGRHESRS MRIFSTESLL
SRNSESPEHV PSQAGNAFQE HTAHIHATEY AVGIYDNAMV PQMCGNLTPS AHCINVRASR
DCASISSEDS HDYVNVPTAE EIAETLASTK SPSRNLFVLP STQKLEFTEE RDEGCGDAGD
CTSLYSPGAE DSDSLSNGEG SSQISNDYVN MTGLDLSAIQ ERQLWVAFQC CRDYENVPAA
DPSGSQQQAE KDVPSSNIGH VEDKTDDPGT HVQCVKRTFL ASGDYADFQP FTQSEDSQMK
HREEMSNEDS SDYENVLTAK LGGRDSEQGP GTQLLPDE
Records:
Category Evidence Reference
A Inference Zhu M, Janssen E, Leung K, Zhang W., Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling, [12359715]
End of Record Details