ul_28----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name CDC25B( Description: cell division cycle 25 homolog B (S. pombe). )
Synonyms Dual specificity phosphatase Cdc25B; EC 3.1.3.48
GO annotations GO_component: intracellular
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 9188863]
GO_process: cell division; M phase of mitotic cell cycle; mitosis [PMID 1836978]; positive regulation of cell proliferation [PMID 8276402]; protein amino acid dephosphorylation; regulation of progression through cell cycle [PMID 1836978]
RefSeq accession NP_004349
SwissProt accession P30305
Sequence:(RefSeq accession:NP_004349; substrate region highlighted if known)
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541
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH
DLAGLGSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA EQTFEQAIQA
ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR NITNSQAPDG RRKSEAGSGA ASSSGEDKEN
DGFVFKMPWK PTHPSSTHAL AEWASRREAF AQRPSSAPDL MCLSPDRKME VEELSPLALG
RFSLTPAEGD TEEDDGFVDI LESDLKDDDA VPPGMESLIS APLVKTLEKE EEKDLVMYSK
CQRLFRSPSM PCSVIRPILK RLERPQDRDT PVQNKRRRSV TPPEEQQEAE EPKARVLRSK
SLCHDEIENL LDSDHRELIG DYSKAFLLQT VDGKHQDLKY ISPETMVALL TGKFSNIVDK
FVIVDCRYPY EYEGGHIKTA VNLPLERDAE SFLLKSPIAP CSLDKRVILI FHCEFSSERG
PRMCRFIRER DRAVNDYPSL YYPEMYILKG GYKEFFPQHP NFCEPQDYRP MNHEAFKDEL
KTFRLKTRSW AGERSRRELC SRLQDQ
Records:
Category Evidence Reference
A Mutagenesis Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ., Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase., [11333986]
End of Record Details