ul_2807----
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PPBD protein
Gene name GRB10
Synonyms GRB10 adaptor protein; Insulin receptor-binding protein GRB-IR
GO annotations GO_component: cytoplasm [PMID 9006901]; plasma membrane [PMID 9006901]
GO_function:protein binding [PMID 8798570]; SH3/SH2 adaptor activity [PMID 9006901]
GO_process: cell-cell signaling [PMID 9006901]; insulin receptor signaling pathway [PMID 9006901]; intracellular signaling cascade
RefSeq accession NP_005302
SwissProt accession Q13322
Substrate protein
Gene name Ephb1( Description: Eph receptor B1. )
Synonyms 9330129L11; AW488255; Cek6; Elk; Elkh; Hek6; Net
GO annotations GO_component: cytoplasm; integral to plasma membrane; lipid raft; membrane
GO_function:axon guidance receptor activity; transmembrane-ephrin receptor activity
GO_process: axon guidance
RefSeq accession NP_775623
SwissProt accession
Sequence:(RefSeq accession:NP_775623; substrate region highlighted if known)
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MALDCLLLFL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV
CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV
IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY
GACMSLLSVR VFFIKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC
NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPSEASPI
CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC
KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP
QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN
SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP
LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAAYSDKLQ HYSTGRGSPG MKIYIDPFTY
EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK
QRRDFLSEAS IMGQFDHRNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ
LVGMLRGIAA GMKYLSEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS
SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD
YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ
PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGVTLAG
HQKKILSSIH SMRVQMNQSP SVMA
Records:
Category Evidence Reference
A Mutagenesis Stein E, Cerretti DP, Daniel TO., Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells, [8798570]
A Inference Smalla M, Schmieder P, Kelly M, Ter Laak A, Krause G, Ball L, Wahl M, Bork P, Oschkinat H., Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites, [10548040]
End of Record Details