ul_2850----
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PPBD protein
Gene name GRB14( Description: growth factor receptor-bound protein 14. )
Synonyms
GO annotations GO_component:
GO_function:SH3/SH2 adaptor activity [PMID 8647858]
GO_process: intracellular signaling cascade
RefSeq accession NP_004481
SwissProt accession Q14449
Substrate protein
Gene name TEK( Description: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal). )
Synonyms CD202B; CD202b antigen; EC 2.7.10.1; TIE-2; TIE2; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1; hTIE2; p140 TEK
GO annotations GO_component: integral to plasma membrane [PMID 8382358]; membrane
GO_function:ATP binding; kinase activity; nucleotide binding; receptor activity [PMID 10766762]; transferase activity; transmembrane receptor protein tyrosine kinase activity [PMID 8382358]
GO_process: cell-cell signaling [PMID 8980225]; protein amino acid phosphorylation; signal transduction [PMID 8382358]; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 8980225]
RefSeq accession NP_000450
SwissProt accession Q02763
Sequence:(RefSeq accession:NP_000450; substrate region highlighted if known)
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MDSLASLVLC GVSLLLSGTV EGAMDLILIN SLPLVSDAET SLTCIASGWR PHEPITIGRD
FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY FCEGRVRGEA IRIRTMKMRQ
QASFLPATLT MTVDKGDNVN ISFKKVLIKE EDAVIYKNGS FIHSVPRHEV PDILEVHLPH
AQPQDAGVYS ARYIGGNLFT SAFTRLIVRR CEAQKWGPEC NHLCTACMNN GVCHEDTGEC
ICPPGFMGRT CEKACELHTF GRTCKERCSG QEGCKSYVFC LPDPYGCSCA TGWKGLQCNE
ACHPGFYGPD CKLRCSCNNG EMCDRFQGCL CSPGWQGLQC EREGIPRMTP KIVDLPDHIE
VNSGKFNPIC KASGWPLPTN EEMTLVKPDG TVLHPKDFNH TDHFSVAIFT IHRILPPDSG
VWVCSVNTVA GMVEKPFNIS VKVLPKPLNA PNVIDTGHNF AVINISSEPY FGDGPIKSKK
LLYKPVNHYE AWQHIQVTNE IVTLNYLEPR TEYELCVQLV RRGEGGEGHP GPVRRFTTAS
IGLPPPRGLN LLPKSQTTLN LTWQPIFPSS EDDFYVEVER RSVQKSDQQN IKVPGNLTSV
LLNNLHPREQ YVVRARVNTK AQGEWSEDLT AWTLSDILPP QPENIKISNI THSSAVISWT
ILDGYSISSI TIRYKVQGKN EDQHVDVKIK NATITQYQLK GLEPETAYQV DIFAENNIGS
SNPAFSHELV TLPESQAPAD LGGGKMLLIA ILGSAGMTCL TVLLAFLIIL QLKRANVQRR
MAQAFQNVRE EPAVQFNSGT LALNRKVKNN PDPTIYPVLD WNDIKFQDVI GEGNFGQVLK
ARIKKDGLRM DAAIKRMKEY ASKDDHRDFA GELEVLCKLG HHPNIINLLG ACEHRGYLYL
AIEYAPHGNL LDFLRKSRVL ETDPAFAIAN STASTLSSQQ LLHFAADVAR GMDYLSQKQF
IHRDLAARNI LVGENYVAKI ADFGLSRGQE VYVKKTMGRL PVRWMAIESL NYSVYTTNSD
VWSYGVLLWE IVSLGGTPYC GMTCAELYEK LPQGYRLEKP LNCDDEVYDL MRQCWREKPY
ERPSFAQILV SLNRMLEERK TYVNTTLYEK FTYAGIDCSA EEAA
Records:
Category Evidence Reference
A Peptide affinity isolation Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration, [10521483]
End of Record Details