ul_2875----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name let-23( Description: LEThal. )
Synonyms
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_495962
SwissProt accession
Sequence:(RefSeq accession:NP_495962; substrate region highlighted if known)
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MRYPPSIGSI LLIIPIFLTF FGNSNAQLWK RCVSPQDCLC SGTTNGISRY GTGNILEDLE
TMYRGCRRVY GNLEITWIEA NEIKKWREST NSTVDPKNED SPLKSINFFD NLEEIRGSLI
IYRANIQKIS FPRLRVIYGD EVFHDNALYI HKNDKVHEVV MRELRVIRNG SVTIQDNPKM
CYIGDKIDWK ELLYDPDVQK VETTNSHQHC YQNGKSMAKC HESCNDKCWG SGDNDCQRVY
RSVCPKSCSQ CFYSNSTSSY ECCDSACLGG CTGHGPKNCI ACSKYELDGI CIETCPSRKI
FNHKTGRLVF NPDGRYQNGN HCVKECPPEL LIENDVCVRH CSDGHHYDAT KDVRECEKCR
SSSCPKICTV DGHLTNETLK NLEGCEQIDG HLIIEHAFTY EQLKVLETVK IVSEYITIVQ
QNFYDLKFLK NLQIIEGRKL HNVRWALAIY QCDDLEELSL NSLKLIKTGA VLIMKNHRLC
YVSKIDWSSI ITSKGKDNKP SLAIAENRDS KLCETEQRVC DKNCNKRGCW GKEPEDCLEC
KTWKSVGTCV EKCDTKGFLR NQTSMKCERC SPECETCNGL GELDCLTCRH KTLYNSDFGN
RMECVHDCPV SHFPTQKNVC EKCHPTCYDN GCTGPDSNLG YGGCKQCKYA VKYENDTIFC
LQSSGMNNVC VENDLPNYYI STYDTEGVIE THCEKCSISC KTCSSAGRNV VQNKCVCKHV
EYQPNPSERI CMDQCPVNSF MVPDTNNTVC KKCHHECDQN YHCANGQSTG CQKCKNFTVF
KGDIAQCVSE CPKNLPFSNP ANGECLDYDI ASRQRKTRMV IIGSVLFGFA VMFLFILLVY
WRCQRIGKKL KIAEMVDMPE LTPIDASVRP NMSRICLIPS SELQTKLDKK LGAGAFGTVF
AGIYYPKRAK NVKIPVAIKV FQTDQSQTDE MLEEATNMFR LRHDNLLKII GFCMHDDGLK
IVTIYRPLGN LQNFLKLHKE NLGAREQVLY CYQIASGMQY LEKQRVVHRD LATRNVLVKK
FNHVEITDFG LSKILKHDAD SITIKSGKVA IKWLAIEIFS KHCYTHASDV WAFGVTCWEI
ITFGQSPYQG MSTDSIHNFL KDGNRLSQPP NCSQDLYQEL LRCWMADPKS RPGFEILYER
FKEFCKVPQL FLENSNKISE SDLSAEERFQ TERIREMFDG NIDPQMYFDQ GSLPSMPSSP
TSMATFTIPH GDLMNRMQSV NSSRYKTEPF DYGSTAQEDN SYLIPKTKEV QQSAVLYTAV
TNEDGQTELS PSNGDYYNQP NTPSSSSGYY NEPHLKTKKP ETSEEAEAVQ YENEEVSQKE
TCL
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details