ul_2877----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name Sos( Description: Son of sevenless. )
Synonyms 2.3; 34Ea; BG:DS00941.4; CG7793; E(sev)2A; EK2-8; EY2-3; SOS; Sos1; Su(tor)2-2; br24; br25; dSos; dme-SOS; l(2)34Ea; l(2)br24; l(2)br25; l(2)k05224; l(2)k06321
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_476597
SwissProt accession
Sequence:(RefSeq accession:NP_476597; substrate region highlighted if known)
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MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA GLQDCDGYDF
TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK LCLRLLAMLC AKPLPHSVQD
VEEKVNKSFP APIDQWALNE AKEVINSKKR KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL
VAVLEYISAD ILKMAGDYVI KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL
PAQRASATYE ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE
VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ ASRDALNNLL
SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY IKHLKDLSSS QDDIESFEQV
QGLLHPLHCD LEKVMASLSK ERQVPVSGRV RRQLAIERTR ELQMKVEHWE DKDVGQNCNE
FIREDSLSKL GSGKRIWSER KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR
VDINDRPDSD DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL
QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI ERLTYHIYAD
PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT GTAGAGGMGG VGGDKEHKNS
HREDWKRYRK EYVQPVQFRV LNVLRHWVDH HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW
VDSVLKIVQR KNEQEKSNKK IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL
EFEMYKNVKP SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI
MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL EECRELSDDH
LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT ELINFSKRRK VAEIIGEIQQ
YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK QMSDYLYNES LRIEPRGCKT VPKFPRKWPH
IPLKSPGIKP RRQNQTNSSS KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT
AAAANAGSGT LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA
PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS DTEAPPSPLP
KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS GGEEFCAGGF YFNSAHQGQP
GAVPISPHVN VPMATNMEYR AVPPPLPPRR KERTESCADM AQKRQAPDAP TLPPRDGELS
PPPIPPRLNH STGISYLRQS HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN
QAAAGPISTT LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST
SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS SPKEFFPIAT
SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details