ul_2884----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name IL7R( Description: interleukin 7 receptor. )
Synonyms CD127; CD127 antigen; CDW127; CDw127; IL-7R-alpha
GO annotations GO_component: integral to membrane; membrane
GO_function:antigen binding [PMID 9495344]; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-7 receptor activity [PMID 8266077]; protein binding [PMID 8266077]; receptor activity
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 9495344]; cell surface receptor linked signal transduction [PMID 9843216]; immune response [PMID 9843216]; regulation of DNA recombination [PMID 9495344]
RefSeq accession NP_002176
SwissProt accession P16871
Sequence:(RefSeq accession:NP_002176; substrate region highlighted if known)
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MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE
DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK
IDLTTIVKPE APFDLSVVYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details