ul_2993----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P29354
Substrate protein
Gene name Efgr( Description: epidermal growth factor receptor. )
Synonyms ERBB1; ErbB-1; Errp
GO annotations GO_component: AP-2 adaptor complex; basolateral plasma membrane; cytoplasm; cytoskeleton; endocytic vesicle; endosome; extracellular space; integral to membrane; integral to plasma membrane; intracellular; nucleus; plasma membrane
GO_function:actin filament binding; double-stranded DNA binding; epidermal growth factor receptor activity; kinase activity; MAP/ERK kinase kinase activity; nitric-oxide synthase regulator activity; protein binding; protein heterodimerization activity; signal transducer activity; transmembrane receptor activity
GO_process: calcium-dependent phospholipase A2 activation; cell morphogenesis; cell proliferation; cell surface receptor linked signal transduction; cell-cell adhesion; epidermal growth factor receptor signaling pathway; ossification; phospholipase C activation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of MAPK activity; positive regulation of nitric oxide biosynthesis; positive regulation of phosphorylation; protein amino acid autophosphorylation; protein biosynthesis; protein insertion into membrane; protein kinase cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to stress; signal transduction
RefSeq accession NP_113695
SwissProt accession
Sequence:(RefSeq accession:NP_113695; substrate region highlighted if known)
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MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA
VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV
QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC
TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK
YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF
ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL
FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN
ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM
GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV
VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG
SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG
ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA
ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS
YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP
KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP
QQGFFNSPST SRTPLLSSLS ANSNSSTVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN
IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT
AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA
PPSSEFSGA
Records:
Category Evidence Reference
A Peptide library Ribon V, Saltiel AR., Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells, [8631760]
End of Record Details