ul_3032----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name IRS-1( Description: insulin receptor substrate 1. )
Synonyms
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_001026741
SwissProt accession
GO Pathway:
GO:0007165     signal transduction
Sequence:(RefSeq accession:NP_001026741; substrate region highlighted if known)
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MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGA PGVEYYENEK KWWHKSSAPK
RSIPLESCFN INKQVGDKNK HLVALYTRDE HFAIAADSEA EQDSWYQALL PLHNRAKGHH
DGAAALGGGG GGSCSSSASL GEAGEDLSYG DGAPGPAFKE VWQVILKPKG LGQTKNLIGI
YRLCLTSKTI SFVKLNSDAA AVVLQLLNIR RCGHSENFFF IEVGRSAVTV PGEFWMQVDD
SVVAQNMHET ILEAMRAMSE EFRPRSKSQS SSNCSNPISV PLRRHHINNP PPSQVGLSRR
SRTESVTATS PAGGVGGKPS SFRVRESSDG EGTMSPPDQQ DGSPVSPSTN RTHAHRHRGS
ALLQPPLNHS RSIPMPASRC SPSATSPVSL SSSSTSGHGS TSDCLFPRRS SASVSGSPSD
GGFISSDEYG SSPCDFRSSF RSVTPDSLGH TPPARGEEEL SNYICMGGKG PSTLTAPNGH
YILSRGANGH RCTPGTGLGT SPALAGDEQT SAADLDNRFR KRTHSAGTSP TITHQKTPSQ
SSVASIEEYT EMMPAYPPGG GSGGRAWPGR LSAFVPTRSY PEEGLEMHPL ERRAGRTSPD
SSTLHTDDGY MPMSPGWPPV SSGRKGNGDY MSMSPKSVST PQQIINPITG PSERVYPNGY
MMMSHSGGCS PDIGGGPSSS SSSSNAVPSG TSYGKLWTNG VGGHHSHVLP HPKPPVESSG
GKLLPCTGDY MDMYPVGDSN TSDPSLSYYG PEDPQHKPVL SYYSLPDAFK HPSGPGEPEE
GARHQHLRLS TSSGRLLYAA TADDSSSSTS SDTLGGGYCG ARLEPRLPHP HHQVLQPHLA
RKVDTSLAQT NSRLARPTRL SLGDPKASTL PRAREQQQQS QPFACPPEPK SPGEYVNIEF
GSDQSGYLSG PVAFHSSPSV RCPSQLQPAP REEETGTEEY MKMDLGPGRR AAWQERTGVE
MGRLGPAPPG AASICRPTAV PSSRGDYMTM QMSCPRQSYV DTSPAAPVSY ADMRTGIAAE
EVSLPRATIA AASSSSTTSA SDWARQAPEL AAHFVLLGGP QGPGGMSGSF TRANLSPNRN
QSAKVIRADT QGCRRIASSQ TLSSTPSSTR WHTHVPLRAG AAVGGIRVSA SSEQDVKPHS
SASFENVWLR PGELGGAPKE PAKLCGAAGG LENGLNYIDL DLVKDFKQCP QECTPEPQPP
PPPPPHQPLG SGESSSTRRS SEDLSAYAST SFQKQPEDRQ
Records:
Category Evidence Reference
A Inference Taouis M, Taylor SI, Reitman M., Cloning of the chicken insulin receptor substrate 1 gene, [8921891]
End of Record Details