ul_3074----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P62993
Substrate protein
Gene name SHC( Description: src homology 2 domain-containing transforming protein C1. )
Synonyms Shc; ShcA; p66
GO annotations GO_component: plasma membrane
GO_function:phospholipid binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity
GO_process: activation of MAPK activity; intracellular signaling cascade; positive regulation of cell proliferation; positive regulation of mitosis; regulation of cell growth
RefSeq accession NP_035498
SwissProt accession
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_035498; substrate region highlighted if known)
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MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV
EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM
PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL
ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY
NDFPGKEPPL GGVVDMRLRE GAARPTLPSA QMSSHLGATL PIGQHAAGDH EVRKQMLPPP
PCPGRELFDD PSYVNIQNLD KARQAGGGAG PPNPSLNGSA PRDLFDMKPF EDALRVPPPP
QSMSMAEQLQ GEPWFHGKLS RREAEALLQL NGDFLVREST TTPGQYVLTG LQSGQPKHLL
LVDPEGVVRT KDHRFESVSH LISYHMDNHL PIISAGSELC LQQPVDRKV
Records:
Category Evidence Reference
A Mutagenesis Harmer SL, DeFranco AL., Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes, [9199344]
End of Record Details