ul_3148----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name ADRB2( Description: adrenergic, beta-2-, receptor, surface. )
Synonyms ADRB2R; ADRBR; B2AR; BAR; BETA2AR; Beta-2 adrenoceptor; Beta-2 adrenoreceptor
GO annotations GO_component: endosome [PMID 10734107]; integral to plasma membrane [PMID 9228019]; lysosome [PMID 9507004]; plasma membrane [PMID 10734107]; receptor complex [PMID 15123695]
GO_function:beta2-adrenergic receptor activity [PMID 15123695]; norepinephrine binding [PMID 15123695]; protein binding [PMID 9560162]; protein homodimerization activity [PMID 15123695]; receptor activity; rhodopsin-like receptor activity
GO_process: activation of MAPK activity [PMID 9924018]; adenylate cyclase activation [PMID 15123695]; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway [PMID 15123695]; endosome to lysosome transport [PMID 9507004]; G-protein coupled receptor protein signaling pathway [PMID 9924018]; G-protein signaling, coupled to cAMP nucleotide second messenger [PMID 2823249]; positive regulation of MAPKKK cascade [PMID 15123695]; protein kinase cascade [PMID 10734107]; receptor mediated endocytosis [PMID 15123695]; transmembrane receptor protein tyrosine kinase activation (dimerization) [PMID 10734107]
RefSeq accession NP_000015
SwissProt accession P07550
GO Pathway:
GO:0007186     G-protein coupled receptor protein signaling pathway
Sequence:(RefSeq accession:NP_000015; substrate region highlighted if known)
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MGQPGNGSAF LLAPNRSHAP DHDVTQQRDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK
FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS
IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE
AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF
HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT
GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL
Records:
Category Evidence Reference
A Mutagenesis Karoor V, Wang L, Wang HY, Malbon CC., Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350, [9830057]
End of Record Details