ul_3182----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name PTPRE( Description: protein tyrosine phosphatase, receptor type, E. )
Synonyms DKFZp313F1310; EC 3.1.3.48; HPTPE; PTPE; Protein-tyrosine phosphatase epsilon; R-PTP-EPSILON; R-PTP-epsilon
GO annotations GO_component: cytoplasm; integral to plasma membrane; membrane; soluble fraction
GO_function:hydrolase activity; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity [PMID 2170109]
GO_process: protein amino acid dephosphorylation [PMID 2170109]
RefSeq accession NP_006495
SwissProt accession P23469
GO Pathway:
GO:0004872     receptor activity
Sequence:(RefSeq accession:NP_006495; substrate region highlighted if known)
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MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW LLLPLLLLLL
VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM LLSRSPSGPK KYFPIPVEHL
EEEIRIRSAD DCKQFREEFN SLPSGHIQGT FELANKEENR EKNRYPNILP NDHSRVILSQ
LDGIPCSDYI NASYIDGYKE KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK
EEKCHQYWPD QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS
WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA MMAMMHAEQK
VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTMHGTTTH
FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD
YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW
PTEGSVTHGE ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI
PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ
AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK
Records:
Category Evidence Reference
A Mutagenesis Toledano-Katchalski H, Elson A., The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2, [10490839]
End of Record Details