ul_3186----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P29354
Substrate protein
Gene name Sh2d2a( Description: SH2 domain protein 2A. )
Synonyms Lad; Ribp; TSAd
GO annotations GO_component:
GO_function:protein binding; SH3/SH2 adaptor activity
GO_process: cell proliferation; intracellular signaling cascade
RefSeq accession NP_067284
SwissProt accession
Sequence:(RefSeq accession:NP_067284; substrate region highlighted if known)
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MEFCLAQPCP QGNHEATSST FNTFQPMNLT QGRCQNLSCG SRPSMQVMKE QGVQLSPRTN
HTVVSASAPG TAWVLGNADR AEEVPGKGDL SLQAETRAWV QKTQAHWLLL KTAPLWFHGF
ITRREAERLL QPQPLGCYLV RFSESAVTFV LSYRSQTCCR HFLLAQLGDG RHVVLGEDSA
HAQLQDLLEH YTECPLSPYG EILTQPLARQ TAEPAGLSLR ADSDSGSKRQ DPDTQLSLLL
QQGQAQASGH TEKVWASQQK ATSQASRPRP PIPAKPQLPP EVYTSPASRL HQAPPINPIY
QEPDEPIAFY AMGRGSPGDA PSNIYAEVEG PSGTAPIGHP ILRKCWSRPI SRGQVREVQG
KISSRSRAER GSPS
Records:
Category Evidence Reference
A Inference Choi YB, Kim CK, Yun Y., Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation, [10553045]
End of Record Details