ul_3191----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P29354
Substrate protein
Gene name PTPRA
Synonyms EC 3.1.3.48; Protein-tyrosine phosphatase alpha; R-PTP-alpha
GO annotations GO_component: integral to plasma membrane [PMID 2169617]; membrane
GO_function:hydrolase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity [PMID 2169617]
GO_process: protein amino acid dephosphorylation
RefSeq accession NP_002827
SwissProt accession P18433
Sequence:(RefSeq accession:NP_002827; substrate region highlighted if known)
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MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS
VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP
WEGNSSTAAT TPETFPPSGN SDSKDRRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY
KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL
FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW
TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM
LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ
RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL
TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV
ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ
QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ
YEFCYKVVQE YIDAFSDYAN FK
Records:
Category Evidence Reference
A Mutagenesis Zheng XM, Resnick RJ, Shalloway D., A phosphotyrosine displacement mechanism for activation of Src by PTPalpha, [10698938]
End of Record Details