ul_3237----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name CD22( Description: CD22 antigen. )
Synonyms A530093D23; Lyb-8; Lyb8
GO annotations GO_component: external side of plasma membrane; integral to plasma membrane; membrane
GO_function:coreceptor activity; protein binding; sugar binding
GO_process: cell adhesion; cell surface receptor linked signal transduction; defense response
RefSeq accession NP_033975
SwissProt accession
GO Pathway:
GO:0007166     cell surfuce receptor linked signal transduction
Sequence:(RefSeq accession:NP_033975; substrate region highlighted if known)
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MRVHYLWLLL ILGHVASARY SSANDWTVDH PQTLFAWEGA CIRIPCKYKT PLPKARLDNI
LLFQNYEFDK ATKKFTGTVL YNATKTEKDP ESELYLSKQG RVTFLGNRID NCTLKIHPIR
ANDSGNLGLR MTAGTERWME PIHLNVSEKP FQPYIQMPSE IRESQSVTLT CGLNFSCFGY
DILLKWFLED SEITSITSSV TSITSSVTSS IKNVYTESKL TFQPKWTDHG KSVKCQVQHS
SKVLSERTVR LDVKYTPKLE IKVNPTEVEK NNSVTMTCRV NSSNPKLRTV AVSWFKDGRP
LEDQELEQEQ QMSKLILHSV TKDMRGKYRC QASNDIGPGE SEEVELTVHY APEPSRVHIY
PSPAEEGQSV ELICESLASP SATNYTWYHN RKPIPGDTQE KLRIPKVSPW HAGNYSCLAE
NRLGHGKIDQ EAKLDVHYAP KAVTTVIQSF TPILEGDSVT LVCRYNSSNP DVTSYRWNPQ
GSGSVLKPGV LRIQKVTWDS MPVSCAACNH KCSWALPVIL NVHYAPRDVK VLKVSPASEI
RAGQRVLLQC DFAESNPAEV RFFWKKNGSL VQEGRYLSFG SVSPEDSGNY NCMVNNSIGE
TLSQAWNLQV LYAPRRLRVS ISPGDHVMEG KKATLSCESD ANPPISQYTW FDSSGQDLHS
SGQKLRLEPL EVQHTGSYRC KGTNGIGTGE SPPSTLTVYY SPETIGKRVA LGLGFCLTIC
ILAIWGMKIQ KKWKQNRSQQ GLQENSSGQS FFVRNKKARR TPLSEGPQSQ GCYNPAMDDT
VSYAILRFPE SDTHNTGDAG TPATRAPPPN NSDSVTYSVI QKRPMGDYEN VNPSCPEDES
IHYSELVQFG AGKRPQAKED VDYVTLKH
Records:
Category Evidence Reference
A Mutagenesis Otipoby KL, Draves KE, Clark EA., CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1, [11551923]
End of Record Details