ul_3260----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name ETV6( Description: ets variant gene 6 (TEL oncogene). )
Synonyms ETS translocation variant 6; ETS-related protein Tel1; TEL; TEL/ABL; Tel
GO annotations GO_component: nucleus
GO_function:sequence-specific DNA binding; transcription factor activity [PMID 7761424]
GO_process: regulation of transcription, DNA-dependent; transcription
RefSeq accession NP_001978
SwissProt accession P41212
GO Pathway:
GO:0007265     Ras protein signal transduction
Sequence:(RefSeq accession:NP_001978; substrate region highlighted if known)
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MSETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY
WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI
LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH
RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM
ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE
GKPINLSHRE DLAYMNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW
EDKESKIFRI VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM
KTPDEIMSGR TDRLEHLESQ ELDEQIYQED EC
Records:
Category Evidence Reference
A Mutagenesis Ho JM, Nguyen MH, Dierov JK, Badger KM, Beattie BK, Tartaro P, Haq R, Zanke BW, Carroll MP, Barber DL., TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways, [12149229]
End of Record Details