ul_3272----
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PPBD protein
Gene name GRB2
Synonyms Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P62993
Substrate protein
Gene name LAT2
Synonyms Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosome region 15 protein
GO annotations GO_component: integral to membrane; lipid raft [PMID 12486104]; membrane
GO_function:protein binding [PMID 14722116]; SH2 domain binding [PMID 14722116]
GO_process: B cell activation [PMID 14722116]; calcium-mediated signaling [PMID 14722116]; immune response; intracellular signaling cascade [PMID 14722116]; mast cell degranulation
RefSeq accession NP_071323
SwissProt accession Q9GZY6
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_071323; substrate region highlighted if known)
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MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL
VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN
WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP
SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA
TEA
Records:
Category Evidence Reference
A Inference Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W., LAB: a new membrane-associated adaptor molecule in B cell activation, [12514734]
End of Record Details