ul_3290----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_002077
SwissProt accession P29354
Substrate protein
Gene name Lat( Description: linker for activation of T cells. )
Synonyms
GO annotations GO_component: immunological synapse; integral to membrane; integral to plasma membrane; membrane
GO_function:protein binding; receptor signaling protein activity; SH3/SH2 adaptor activity
GO_process: calcium-mediated signaling; cellular defense response; immune response; integrin-mediated signaling pathway; intracellular signaling cascade; mast cell degranulation; Ras protein signal transduction; regulation of T cell activation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_034819
SwissProt accession
Sequence:(RefSeq accession:NP_034819; substrate region highlighted if known)
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MEADALSPVG LGLLLLPFLV TLLAALCVRC RELPVSYDST STESLYPRSI LIKPPQITVP
RTPAVSYPLV TSFPPLRQPD LLPIPRSPQP LGGSHRMPSS QQNSDDANSV ASYENQEPAC
KNVDADEDED DYPNGYLVVL PDSSPAAVPV VSSAPVPSNP DLGDSAFSVE SCEDYVNVPE
SEESAEASLD GSREYVNVSP EQQPVTRAEL ASVNSQEVED EGEEEGVDGE EAPDYENLQE
LN
Records:
Category Evidence Reference
A Mutagenesis Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE., The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation, [12953098]
End of Record Details