ul_330----
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PPBD protein
Gene name YWHAE( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide. )
Synonyms 14-3-3E; FLJ45465; KCIP-1; MDCR; MDS
GO annotations GO_component:
GO_function:enzyme binding [PMID 10788521]; protein domain specific binding
GO_process:
RefSeq accession NP_006752
SwissProt accession P62258
Substrate protein
Gene name KCNH2( Description: potassium voltage-gated channel, subfamily H (eag-related), member 2. )
Synonyms ERG1; Eag-related protein 1; Erg1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go-related protein 1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1; Voltage-gated potassium channel subunit Kv11.1; eag homolog
GO annotations GO_component: integral to membrane; membrane; membrane fraction; voltage-gated potassium channel complex [PMID 7736582]
GO_function:delayed rectifier potassium channel activity [PMID 7736582]; potassium ion binding; two-component sensor activity
GO_process: ion transport; muscle contraction [PMID 7736582]; potassium ion transport [PMID 7736582]; regulation of heart contraction [PMID 7736582]; regulation of transcription, DNA-dependent; sensory perception of sound; two-component signal transduction system (phosphorelay)
RefSeq accession NP_000229
SwissProt accession Q12809
GO Pathway:
GO:0008016     regulation of heart contraction
Sequence:(RefSeq accession:NP_000229; substrate region highlighted if known)
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MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM
QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG
AVIMFILNFE VVMEKDMVGS PAHDTNHRGP PTSWLAPGRA KTFRLKLPAL LALTARESSV
RSGGAGGAGA PGAVVVDVDL TPAAPSSESL ALDEVTAMDN HVAGLGPAEE RRALVGPGSP
PRSAPGQLPS PRAHSLNPDA SGSSCSLART RSRESCASVR RASSADDIEA MRAGVLPPPP
RHASTGAMHP LRSGLLNSTS DSDLVRYRTI SKIPQITLNF VDLKGDPFLA SPTSDREIIA
PKIKERTHNV TEKVTQVLSL GADVLPEYKL QAPRIHRWTI LHYSPFKAVW DWLILLLVIY
TAVFTPYSAA FLLKETEEGP PATECGYACQ PLAVVDLIVD IMFIVDILIN FRTTYVNANE
EVVSHPGRIA VHYFKGWFLI DMVAAIPFDL LIFGSGSEEL IGLLKTARLL RLVRVARKLD
RYSEYGAAVL FLLMCTFALI AHWLACIWYA IGNMEQPHMD SRIGWLHNLG DQIGKPYNSS
GLGGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF SICVMLIGSL MYASIFGNVS
AIIQRLYSGT ARYHTQMLRV REFIRFHQIP NPLRQRLEEY FQHAWSYTNG IDMNAVLKGF
PECLQADICL HLNRSLLQHC KPFRGATKGC LRALAMKFKT THAPPGDTLV HAGDLLTALY
FISRGSIEIL RGDVVVAILG KNDIFGEPLN LYARPGKSNG DVRALTYCDL HKIHRDDLLE
VLDMYPEFSD HFWSSLEITF NLRDTNMIPG SPGSTELEGG FSRQRKRKLS FRRRTDKDTE
QPGEVSALGP GRAGAGPSSR GRPGGPWGES PSSGPSSPES SEDEGPGRSS SPLRLVPFSS
PRPPGEPPGG EPLMEDCEKS SDTCNPLSGA FSGVSNIFSF WGDSRGRQYQ ELPRCPAPTP
SLLNIPLSSP GRRPRGDVES RLDALQRQLN RLETRLSADM ATVLQLLQRQ MTLVPPAYSA
VTTPGPGPTS TSPLLPVSPL PTLTLDSLSQ VSQFMACEEL PPGAPELPQE GPTRRLSLPG
QLGALTSQPL HRHGSDPGS
Records:
Category Evidence Reference
A Mutagenesis Kagan A, Melman YF, Krumerman A, McDonald TV., 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity., [11953308]
A Inference Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D., C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon., [16923798]
End of Record Details