ul_330----<table width="100%" border="0" cellpadding="5" cellspacing="1" bgcolor="#666666" >
    <tr>
    <td colspan="2" bgcolor="#999999"><table width="100%" border="0" cellspacing="0">
        <tr>
          <td width="91%" align="left"><strong>Record details:</strong> </td>
          <td width="9%" align="right"><a href="javascript:hide('ul_330')" class="small">Hide</a></td>
       </tr>
      </table></td>
  </tr>
    <tr bgcolor="#CCCCCC">
    <td colspan="2"><strong>PPBD protein </strong></td>
    
  </tr>
 <tr>
    <td bgcolor="#FFFFFF" colspan="2"><table width="100%" border="0" cellpadding="5" cellspacing="1">
      <tr>
        <td width="25%">Gene name </td>
        <td><a href="ppbd.php?s=YWHAE" title="PPBD proteins are named by using their Entrez Gene Name.">YWHAE</a>( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide. )</td>
      </tr> 
      	<tr>
        <td>Synonyms </td>
        <td>14-3-3E; FLJ45465; KCIP-1; MDCR; MDS</td>
      </tr>
       <tr>
        <td>GO annotations </td>
        <td>GO_component: <br>GO_function:<a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0019899>enzyme binding</a> [PMID <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=10788521>10788521</a>]; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0019904>protein</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0019904>domain specific binding</a><br>GO_process: </td>
      </tr>
      <tr>	
      <tr>
        <td>RefSeq accession </td>
        <td><a href="http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_006752" target="_blank" >NP_006752</a></td>
      </tr>
      <tr>
        <td>SwissProt accession </td>
        <td><a href="http://www.expasy.org/uniprot/P62258" target="_blank" >P62258</a></td>
      </tr>
    </table></td></tr>
    
    <tr bgcolor="#CCCCCC">
    
    <td  colspan="2"><strong>Substrate protein </strong></td>
  </tr>
  <tr>
    <td bgcolor="#FFFFFF" colspan="2"><table width="100%" border="0" cellpadding="5" cellspacing="1">
      <tr>
        <td width="25%">Gene name </td>
        <td><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=full_report&list_uids=3757
" target="_blank"  title="Substrate proteins are named by using their Entrez Gene Name.">KCNH2</a>( Description: potassium voltage-gated channel, subfamily H (eag-related), member 2. )</td>
      </tr>
      	<tr>
        <td>Synonyms </td>
        <td>ERG1; Eag-related protein 1; Erg1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go-related protein 1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1; Voltage-gated potassium channel subunit Kv11.1; eag homolog</td>
      </tr><tr>
        <td>GO annotations </td>
        <td>GO_component: <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0016021>integral to membrane</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0016020>membrane</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0005624>membrane</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0005624>fraction</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0008076>voltage-gated potassium channel complex</a> [PMID
                     <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=7736582>7736582</a>]<br>GO_function:<a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0005251>delayed rectifier potassium channel activity</a>
                     [PMID <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=7736582>7736582</a>]; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0030955>potassium ion binding</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0000155>two-component</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0000155>sensor activity</a><br>GO_process: <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0006811>ion transport</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0006936>muscle contraction</a> [PMID
                     <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=7736582>7736582</a>]; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0006813>potassium ion transport</a> [PMID <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=7736582>7736582</a>];
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0008016>regulation of heart contraction</a> [PMID <a target="_blank" href=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&list_uids=7736582>7736582</a>]; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0006355>regulation</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0006355>of transcription, DNA-dependent</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0007605>sensory perception of</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0007605>sound</a>; <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0000160>two-component signal transduction system</a>
                     <a target="_blank" href=http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0000160>(phosphorelay)</a></td>
      </tr>
      <tr>		
      	<tr>
        <td>RefSeq accession </td>
        <td><a href="http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000229" target="_blank" >NP_000229</a></td>
      </tr>
      <tr>
        <td>SwissProt accession </td>
        <td><a href="http://www.expasy.org/uniprot/Q12809" target="_blank" >Q12809</a></td>
      </tr>
    </table></td>
  </tr><tr>
    <td colspan="2" bgcolor="#CCCCCC"><strong>GO Pathway:</strong></td></tr><tr>
    <td  colspan="2" bgcolor="#FFFFFF"><a href="http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0008016" target="_blank" >GO:0008016</a>&nbsp&nbsp &nbsp   regulation of heart contraction</td></tr><tr>
    <td colspan="2" bgcolor="#CCCCCC"><strong>Sequence:</strong>(RefSeq accession:<a href="http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000229" target="_blank" >NP_000229</a>; substrate region highlighted 
if known)</td></tr><tr bgcolor="#FFFFFF"><td colspan="2"><table align="center"><tr><td class="sequence" align="right">1<br>61<br>121<br>181<br>241<br>301<br>361<br>421<br>481<br>541<br>601<br>661<br>721<br>781<br>841<br>901<br>961<br>1021<br>1081<br>1141<br></td><td><span class="sequence">MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM <br>QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG <br>AVIMFILNFE VVMEKDMVGS PAHDTNHRGP PTSWLAPGRA KTFRLKLPAL LALTARESSV <br>RSGGAGGAGA PGAVVVDVDL TPAAPSSESL ALDEVTAMDN HVAGLGPAEE RRALVGPGSP <br>PRSAPGQLPS PRAHSLNPDA SGSSCSLART RSRE<font color='red'>SCASVR RASSADDIEA M</font>RAGVLPPPP <br>RHASTGAMHP LRSGLLNSTS DSDLVRYRTI SKIPQITLNF VDLKGDPFLA SPTSDREIIA <br>PKIKERTHNV TEKVTQVLSL GADVLPEYKL QAPRIHRWTI LHYSPFKAVW DWLILLLVIY <br>TAVFTPYSAA FLLKETEEGP PATECGYACQ PLAVVDLIVD IMFIVDILIN FRTTYVNANE <br>EVVSHPGRIA VHYFKGWFLI DMVAAIPFDL LIFGSGSEEL IGLLKTARLL RLVRVARKLD <br>RYSEYGAAVL FLLMCTFALI AHWLACIWYA IGNMEQPHMD SRIGWLHNLG DQIGKPYNSS <br>GLGGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF SICVMLIGSL MYASIFGNVS <br>AIIQRLYSGT ARYHTQMLRV REFIRFHQIP NPLRQRLEEY FQHAWSYTNG IDMNAVLKGF <br>PECLQADICL HLNRSLLQHC KPFRGATKGC LRALAMKFKT THAPPGDTLV HAGDLLTALY <br>FISRGSIEIL RGDVVVAILG KNDIFGEPLN LYARPGKSNG DVRALTYCDL HKIHRDDLLE <br>VLDMYPEFSD HFWSSLEITF NLRDTNMIPG SPGSTELEGG FSRQRKRKLS FRRRTDKDTE <br>QPGEVSALGP GRAGAGPSSR GRPGGPWGES PSSGPSSPES SEDEGPGRSS SPLRLVPFSS <br>PRPPGEPPGG EPLMEDCEKS SDTCNPLSGA FSGVSNIFSF WGDSRGRQYQ ELPRCPAPTP <br>SLLNIPLSSP GRRPRGDVES RLDALQRQLN RLETRLSADM ATVLQLLQRQ MTLVPPAYSA <br>VTTPGPGPTS TSPLLPVSPL PTLTLDSLSQ VSQFMACEEL PPGAPELPQE GPTRRLSLPG <br>QLGALTSQPL HRHGSDPGS</span></td></tr></table></td></tr><tr>
    <td colspan="2" bgcolor="#CCCCCC"><strong>Records:</strong></td>
  </tr><tr>
    <td colspan="2" bgcolor="#FFFFFF">
       <table width="90%" align="center" border="0" cellpadding="5" cellspacing="1" bgcolor="#DDDDDD">
          <tr bgcolor="#EFEFEF">
                <td align="center"><b>Category</b></td>
                <td align="center"><b>Evidence</b></td>
                <td align="center"><b>Reference</b></td>
           </tr><tr bgcolor="#FFFFFF">
                <td  align="center">A</td>
                <td  align="center">Mutagenesis</td>
                <td  align="left"><a>Kagan A, Melman YF, Krumerman A, McDonald TV., 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity., [<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11953308" target="_blank" >11953308</a>] </a></td>
            </tr><tr bgcolor="#FFFFFF">
                <td  align="center">A</td>
                <td  align="center">Inference</td>
                <td  align="left"><a>Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D., C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon., [<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16923798" target="_blank" >16923798</a>] </a></td>
            </tr></table></td>
  </tr> <tr>
    <td colspan="2" bgcolor="#999999" align="right"><strong>End of Record Details</strong></td>
  </tr></table>