ul_3305----
Record details: Hide
PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P29354
Substrate protein
Gene name PLD2( Description: phospholipase D2. )
Synonyms Choline phosphatase 2; EC 3.1.4.4; PLD 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2; hPLD2
GO annotations GO_component: plasma membrane [PMID 9395408]
GO_function:hydrolase activity; phosphoinositide binding; phospholipase D activity [PMID 9582313]; protein binding
GO_process: cytoskeleton organization and biogenesis [PMID 9395408]; lipid catabolism; metabolism; small GTPase mediated signal transduction [PMID 9582313]
RefSeq accession NP_002654
SwissProt accession O14939
GO Pathway:
GO:0000165     MPKKK cascade
Sequence:(RefSeq accession:NP_002654; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
MTATPESLFP TGDELDSSQL QMESDEVDTL KEGEDPADRM HPFLAIYELQ SLKVHPLVFA
PGVPVTAQVV GTERYTSGSK VGTCTLYSVR LTHGDFSWTT KKKYRHFQEL HRDLLRHKVL
MSLLPLARFA VAYSPARDAG NREMPSLPRA GPEGSTRHAA SKQKYLENYL NCLLTMSFYR
NYHAMTEFLE VSQLSFIPDL GRKGLEGMIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV
KDSFLLYMCL ETGAISFVQL FDPGFEVQVG KRSTEARHGV RIDTSHRSLI LKCSSYRQAR
WWAQEITELA QGPGRDFLQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD AILRAQEEIF
ITDWWLSPEV YLKRPAHSDD WRLDIMLKRK AEEGVRVSIL LFKEVELALG INSGYSKRAL
MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE
SAASQPPTPR PDSPATPDLS HNQFFWLGKD YSNLITKDWV QLDRPFEDFI DRETTPRMPW
RDVGVVVHGL PARDLARHFI QRWNFTKTTK AKYKTPIYPY LLPKSTSTAN QLPFTLPGGQ
CTTVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG RTVLNKVGDE
IVDRILKAHK QGWCYRVYVL LPLLPGFEGD ISTGGGNSIQ AILHFTYRTL CRGEYSILHR
LKAAMGTAWR DYISICGLRT HGELGGHPVS ELIYIHSKVL IADDRTVIIG SANINDRSLL
GKRDSELAVL IEDTETEPSL MNGAEYQAGR FALSLRKHCF GVILGANTRP DLDLRDPICD
DFFQLWQDMA ESNANIYEQI FRCLPSNATR SLRTLREYVA VEPLATVSPP LARSELTQVQ
GHLVHFPLKF LEDESLLPPL GSKEGMIPLE VWT
Records:
Category Evidence Reference
A Mutagenesis Di Fulvio M, Lehman N, Lin X, Lopez I, Gomez-Cambronero J., The elucidation of novel SH2 binding sites on PLD2, [16407827]
End of Record Details