ul_3316----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P29354
Substrate protein
Gene name DST
Synonyms BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Dystonin; Hemidesmosomal plaque protein; Trabeculin-beta
GO annotations GO_component: basement membrane [PMID 2461961]; cytoplasm [PMID 8575775] [PMID 11751855]; cytoplasmic membrane-bound vesicle [PMID 14581450]; cytoskeleton; extracellular space; hemidesmosome [PMID 8575775] [PMID 11375975]; intercellular junction
GO_function:actin binding; actin filament binding [PMID 8575775]; calcium ion binding; integrin binding [PMID 11375975]; protein binding; protein C-terminus binding [PMID 11375975]; structural constituent of cytoskeleton [PMID 11751855]
GO_process: actin cytoskeleton organization and biogenesis [PMID 8575775]; cell adhesion; cell cycle arrest; cytoskeleton organization and biogenesis [PMID 10428034]; integrin-mediated signaling pathway [PMID 11375975]; intermediate filament cytoskeleton organization and biogenesis [PMID 11375975] [PMID 11751855]
RefSeq accession NP_001714
SwissProt accession O94833
Sequence:(RefSeq accession:NP_001714; substrate region highlighted if known)
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MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE SFDGHRLEML
QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI
DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRILTTEQTK LMISGITQSL
NSGFAQTLHP SLTSGLTQSL TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN
FSSGVEPNSL QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE
WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLTYAEK LHRLESQYAK
LLNTSRNQER HLDTLHNFVS RATNELIWLN EKEEEEVAYD WSERNTNIAR KKDYHAELMR
ELDQKEENIK SVQEIAEQLL LENHPARLTI EAYRAAMQTQ WSWILQLCQC VEQHIKENTA
YFEFFNDAKE ATDYLRNLKD AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTIAN
LMGKAKTIIQ LKPRNSDCPL KTSIPIKAIC DYRQIEITIY KDDECVLANN SHRAKWKVIS
PTGNEAMVPS VCFTVPPPNK EAVDLANRIE QQYQNVLTLW HESHINMKSV VSWHYLINEI
DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES QVFSGSDITQ LEKEVNVCKQ
YYQELLKSAE REEQEESVYN LYISEVRNIR LRLENCEDRL IRQIRTPLER DDLHESVFRI
TEQEKLKKEL ERLKDDLGTI TNKCEEFFSQ AAASSSVPTL RSELNVVLQN MNQVYSMSST
YIDKLKTVNL VLKNTQAAEA LVKLYETKLC EEEAVIADKN NIENLISTLK QWRSEVDEKR
QVFHALEDEL QKAKAISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHV QIDNRLRDLE
GIGKSLKYYR DTYHPLDDWI QQVETTQRKI QENQPENSKT LATQLNQQKM LVSEIEMKQS
KMDECQKYAE QYSATVKDYE LQTMTYRAMV DSQQKSPVKR RRMQSSADLI IQEFMDLRTR
YTALVTLMTQ YIKFAGDSLK RLEEEEIKRC KETSEHGAYS DLLQRQKATV LENSKLTGKI
SELERMVAEL KKQKSRVEEE LPKVREAAEN ELRKQQRNVE DISLQKIRAE SEAKQYRREL
ETIVREKEAA ERELERVRQL TIEAEAKRAA VEENLLNFRN QLEENTFTRR TLEDHLKRKD
LSLNDLEQQK NKLMEELRRK RDNEEELLKL IKQMEKDLAF QKQVAEKQLK EKQKIELEAR
RKITEIQYTC RENALPVCPI TQATSCRAVT GLQQEHDKQK AEELKQQVDE LTAANRKAEQ
DMRELTYELN ALQLEKTSSE EKARLLKDKL DETNNTLRCL KLELERKDQA EKGYSQQLRE
LGRQLNQTTG KAEEAMQEAS DLKKIKRNYQ LELESLNHEK GKLQREVDRI TRAHAVAEKN
IQHLNSQIHS FRDEKELERL QICQRKSDHL KEQFEKSHEQ LLQNIKAEKE NNDKIQRLNE
ELEKSNECAE MLKQKVEELT RQNNETKLMM QRIQAESENI VLEKQTIQQR CEALKIQADG
FKDQLRSTNE HLHKQTKTEQ DFQRKIKCLE EDLAKSQNLV SEFKQKCDQQ NIIIQNTKKE
VRNLNAELNA SKEEKRRGEQ KVQLQQAQVQ ELNNRLKKVQ DELHLKTIEE QMTHRKMVLF
QEESGKFKQS AEEFRKKMEK LMESKVITEN DISGIRLDFV SLQQENSRAQ ENAKLCETNI
KELERQLQQY REQMQQGQHM EANHYQKCQK LEDELIAQKR EVENLKQKMD QQIKEHEHQL
VLLQCEIQKK STAKDCTFKP DFEMTVKECQ HSGELSSRNT GHLHPTPRSP LLRWTQEPQP
LEEKWQHRVV EQIPKEVQFQ PPGAPLEKEK SQQCYSEYFS QTSTELQITF DETNPITRLS
EIEKIRDQAL NNSRPPVRYQ DNACEMELVK VLTPLEIAKN KQYDMHTEVT TLKQEKNPVP
SAEEWMLEGC RASGGLKKGD FLKKGLEPET FQNFDGDHAC SVRDDEFKFQ GLRHTVTARQ
LVEAKLLDMR TIEQLRLGLK TVEEVQKTLN KFLTKATSIA GLYLESTKEK ISFASAAERI
IIDKMVALAF LEAQAATGFI IDPISGQTYS VEDAVLKGVV DPEFRIRLLE AEKAAVGYSY
SSKTLSVFQA MENRMLDRQK GKHILEAQIA SGGVIDPVRG IRVPPEIALQ QGLLNNAILQ
FLHEPSSNTR VFPNPNNKQA LYYSELLRMC VFDVESQCFL FPFGERNISN LNVKKTHRIS
VVDTKTGSEL TVYEAFQRNL IEKSIYLELS GQQYQWKEAM FFESYGHSSH MLTDTKTGLH
FNINEAIEQG TIDKALVKKY QEGLITLTEL ADSLLSRLVP KKDLHSPVAG YWLTASGERI
SVLKASRRNL VDRITALRCL EAQVSTGGII DPLTGKKYRV AEALHRGLVD EGFAQQLRQC
ELVITGIGHP ITNKMMSVVE AVNANIINKE MGIRCLEFQY LTGGLIEPQV HSRLSIEEAL
QVGIIDVLIA TKLKDQKSYV RNIICPQTKR KLTYKEALEK ADFDFHTGLK LLEVSEPLMT
GISSLYYSS
Records:
Category Evidence Reference
A Inference McLaughlin WA, Hou T, Wang W., Prediction of binding sites of peptide recognition domains: an application on Grb2 and SAP SH2 domains, [16476443]
End of Record Details