ul_3322----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P29354
Substrate protein
Gene name PTBP1( Description: polypyrimidine tract binding protein 1. )
Synonyms 57 kDa RNA-binding protein PPTB-1; HNRNPI; HNRPI; Heterogeneous nuclear ribonucleoprotein I; MGC10830; MGC8461; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; hnRNP I; pPTB
GO annotations GO_component: heterogeneous nuclear ribonucleoprotein complex [PMID 1641332]; nucleolus [PMID 1641332]; nucleoplasm [PMID 1641332]; nucleus
GO_function:nucleic acid binding; nucleotide binding; poly-pyrimidine tract binding [PMID 1906036]; protein binding [PMID 10653975] [PMID 16713569]; RNA binding
GO_process: nuclear mRNA splicing, via spliceosome; RNA splicing [PMID 1906036]
RefSeq accession NP_114368
SwissProt accession P26599
Sequence:(RefSeq accession:NP_114368; substrate region highlighted if known)
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MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD SRSAGVPSRV
IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE MNTEEAANTM VNYYTSVTPV
LRGQPIYIQF SNHKELKTDS SPNQARAQAA LQAVNSVQSG NLALAASAAA VDAGMAMAGQ
SPVLRIIVEN LFYPVTLDVL HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS
LDGQNIYNAC CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGLS
VPNVHGALAP LAIPSAAAAA AAAGRIAIPG LAGAGNSVLL VSNLNPERVT PQSLFILFGV
YGDVQRVKIL FNKKENALVQ MADGNQAQLA MSHLNGHKLH GKPIRITLSK HQNVQLPREG
QEDQGLTKDY GNSPLHRFKK PGSKNFQNIF PPSATLHLSN IPPSVSEEDL KVLFSSNGGV
VKGFKFFQKD RKMALIQMGS VEEAVQALID LHNHDLGENH HLRVSFSKST I
Records:
Category Evidence Reference
A Inference McLaughlin WA, Hou T, Wang W., Prediction of binding sites of peptide recognition domains: an application on Grb2 and SAP SH2 domains, [16476443]
End of Record Details