ul_3338----
Record details: Hide
PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P29354
Substrate protein
Gene name PPP1R12A( Description: protein phosphatase 1, regulatory (inhibitor) subunit 12A. )
Synonyms MBS; MGC133042; MYPT1; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; Protein phosphatase myosin-binding subunit
GO annotations GO_component: actin cytoskeleton
GO_function:signal transducer activity [PMID 8662509]
GO_process: regulation of muscle contraction
RefSeq accession NP_002471
SwissProt accession O14974
Sequence:(RefSeq accession:NP_002471; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS GDTDEVLKLL
HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD
IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERIMLRD
ARQWLNSGHI NDVRHAKSGG TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA
HWGKEEACRI LVDNLCDMEM VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKRDKKSP
LIESTANMDN NQSQKTFKNK ETLIIEPEKN ASRIESLEQE KVDEEEEGKK DESSCSSEED
EEDDSESEAE TDKTKPLASV TNANTSSTQA APVAVTTPTV SSGQATPTSP IKKFPTTATK
ISPKEEERKD ESPATWRLGL RKTGSYGALA EITASKEGQK EKDTAGVTRS ASSPRLSSSL
DNKEKEKDSK GTRLAYVAPT IPRRLASTSD IEEKENRDSS SLRTSSSYTR RKWEDDLKKN
SSVNEGSTYH KSCSFGRRQD DLISSSVPST TSTPTVTSAA GLQKSLLSST STTTKITTGS
SSAGTQSSTS NRLWAEDSTE KEKDSVPTAV TIPVAPTVVN AAASTTTLTT TTAGTVSSTT
EVRERRRSYL TPVRDEESES QRKARSRQAR QSRRSTQGVT LTDLQEAEKT IGRSRSTRTR
EQENEEKEKE EKEKQDKEKQ EEKKESETSR EDEYKQKYSR TYDETYQRYR PVSTSSSTTP
SSSLSTMSSS LYASSQLNRP NSLVGITSAY SRGITKENER EGEKREEEKE GEDKSQPKSI
RERRRPREKR RSTGVSFWTQ DSDENEQEQQ SDTEEGSNKK ETQTDSISRY ETSSTSAGDR
YDSLLGRSGS YSYLEERKPY SSRLEKDDST DFKKLYEQIL AENEKLKAQL HDTNMELTDL
KLQLEKATQR QERFADRSLL EMEKRERRAL ERRISEMEEE LKMLPDLKAD NQRLKDENGA
LIRVISKLSK
Records:
Category Evidence Reference
A Inference McLaughlin WA, Hou T, Wang W., Prediction of binding sites of peptide recognition domains: an application on Grb2 and SAP SH2 domains, [16476443]
End of Record Details