ul_3341----

Record details:

PPBD protein

Gene name	GRB2
Synonyms
GO annotations	GO_component: cytosol [PMID 14722116] GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073] GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession	NP_987102
SwissProt accession	P29354

Substrate protein

Gene name	FASLG( Description: Fas ligand (TNF superfamily, member 6). )
Synonyms	APT1LG1; APTL; Apoptosis antigen ligand; CD178; CD178 antigen; CD95L; CD95L protein; FASL; Fas antigen ligand; Fas ligand; TNFSF6
GO annotations	GO_component: extracellular region; extracellular space; integral to plasma membrane [PMID 7826947]; membrane GO_function:signal transducer activity [PMID 12761501]; tumor necrosis factor receptor binding GO_process: apoptosis; cell-cell signaling [PMID 7826947]; immune response; induction of apoptosis [PMID 8787672]; positive regulation of I-kappaB kinase/NF-kappaB cascade [PMID 12761501]; signal transduction [PMID 7826947]
RefSeq accession	NP_000630
SwissProt accession	P48023

Sequence:(RefSeq accession:NP_000630; substrate region highlighted if known)

1
61
121
181
241

MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP
PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ
MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG
LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA
RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

Records:

Category	Evidence	Reference
A	Inference	McLaughlin WA, Hou T, Wang W., Prediction of binding sites of peptide recognition domains: an application on Grb2 and SAP SH2 domains, [16476443]

End of Record Details