ul_3345----
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PPBD protein
Gene name GRB2
Synonyms
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession P29354
Substrate protein
Gene name PTGFRN( Description: prostaglandin F2 receptor negative regulator. )
Synonyms CD315; CD315 antigen; CD9 partner 1; CD9P-1; EWI-F; FLJ11001; FPRP; KIAA1436; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein; SMAP-6
GO annotations GO_component: endoplasmic reticulum; integral to membrane; membrane
GO_function:protein binding [PMID 11278880]
GO_process: negative regulation of protein biosynthesis
RefSeq accession NP_065173
SwissProt accession Q9P2B2
Sequence:(RefSeq accession:NP_065173; substrate region highlighted if known)
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MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF
SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS
TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH
LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA
DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV
RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF
ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK
QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN
IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW
SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL
DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV
HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS
TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD
Records:
Category Evidence Reference
A Peptide affinity isolation Yaoi T, Chamnongpol S, Jiang X, Li X., Src homology 2 domain-based high throughput assays for profiling downstream molecules in receptor tyrosine kinase pathways, [16477079]
End of Record Details