ul_34----
Record details: Hide
PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name WEE1( Description: WEE1 homolog (S. pombe). )
Synonyms DKFZp686I18166; EC 2.7.10.2; FLJ16446; WEE1hu; Wee1A kinase
GO annotations GO_component: nucleus [PMID 8348613]
GO_function:ATP binding; magnesium ion binding; nucleotide binding; protein binding [PMID 15070733]; protein serine/threonine kinase activity; protein-tyrosine kinase activity [PMID 7774574]; transferase activity
GO_process: cell cycle; cell division; mitosis; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8348613]
RefSeq accession NP_003381
SwissProt accession P30291
GO Pathway:
GO:0007049     cell cycle
Sequence:(RefSeq accession:NP_003381; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS
PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG
SSSPVKSPAA PYFLGSSFSP VRCGGPGDAS PRGCGARRAG EGRRSPRPDH PGTPPHKTFR
KLRLFDTPHT PKSLLSKARG IDSSSVKLRG SSLFMDTEKS GKREFDVRQT PQVNINPFTP
DSLLLHSSGQ CRRRKRTYWN DSCGEDMEAS DYELEDETRP AKRITITESN MKSRYTTEFH
ELEKIGSGEF GSVFKCVKRL DGCIYAIKRS KKPLAGSVDE QNALREVYAH AVLGQHSHVV
RYFSAWAEDD HMLIQNEYCN GGSLADAISE NYRIMSYFKE AELKDLLLQV GRGLRYIHSM
SLVHMDIKPS NIFISRTSIP NAASEEGDED DWASNKVMFK IGDLGHVTRI SSPQVEEGDS
RFLANEVLQE NYTHLPKADI FALALTVVCA AGAEPLPRNG DQWHEIRQGR LPRIPQVLSQ
EFTELLKVMI HPDPERRPSA MALVKHSVLL SASRKSAEQL RIELNAEKFK NSLLQKELKK
AQMAKAAAEE RALFTDRMAT RSTTQSNRTS RLIGKKMNRS VSLTIY
Records:
Category Evidence Reference
A Inference Rothblum-Oviatt CJ, Ryan CE, Piwnica-Worms H., 14-3-3 binding regulates catalytic activity of human Wee1 kinase., [11751453]
End of Record Details