ul_3414----
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PPBD protein
Gene name INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms EC 3.1.3.-; Inositol polyphosphate-5-phosphatase of 145 kDa; MGC104855; MGC142140; MGC142142; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP; SHIP-1; SHIP1; SIP-145; hp51CN; p150Ship
GO annotations GO_component:
GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125]
GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession NP_005532
SwissProt accession O00145
Substrate protein
Gene name Fcgr2b( Description: Fc receptor, IgG, low affinity IIb. )
Synonyms AI528646; CD32; F630109E10Rik; Fc[g]RII; FcgRII; Fcgr2; Fcgr2a; Fcr-2; Fcr-3; Ly-17; Ly-m20; LyM-1; Lym-1
GO annotations GO_component: external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane
GO_function:IgG binding; protein binding; receptor activity; receptor signaling protein activity
GO_process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor linked signal transduction; defense response; immune response; immunoglobulin mediated immune response; mast cell activation; negative regulation of B cell proliferation; negative regulation of immune response; negative regulation of type I hypersensitivity; phagocytosis, engulfment; positive regulation of phagocytosis
RefSeq accession NP_034317
SwissProt accession
Sequence:(RefSeq accession:NP_034317; substrate region highlighted if known)
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61
121
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MGILPFLLIP MESNWTVHVF SRTLCHMLLW TAVLNLAAGT HDLPKAVVKL EPPWIQVLKE
DTVTLTCEGT HNPGNSSTQW FHNGRSIRSQ VQASYTFKAT VNDSGEYRCQ MEQTRLSDPV
DLGVISDWLL LQTPQLVFLE GETITLRCHS WRNKLLNRIS FFHNEKSVRY HHYSSNFSIP
KANHSHSGDY YCKGSLGRTL HQSKPVTITV QGPKSSRSLP VLTIVAAVTG IAVAAIVIIL
VSLVYLKKKQ VPDNPPDLEE AAKTEAENTI TYSLLKHPEA LDEETEHDYQ NHI
Records:
Category Evidence Reference
A Peptide library Tridandapani S, Pradhan M, LaDine JR, Garber S, Anderson CL, Coggeshall KM., Protein interactions of Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP): association with Shc displaces SHIP from FcgammaRIIb in B cells, [9973396]
End of Record Details