ul_3418----
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PPBD protein
Gene name INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms EC 3.1.3.-; Inositol polyphosphate-5-phosphatase of 145 kDa; MGC104855; MGC142140; MGC142142; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP; SHIP-1; SHIP1; SIP-145; hp51CN; p150Ship
GO annotations GO_component:
GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125]
GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession NP_005532
SwissProt accession O00145
Substrate protein
Gene name PECAM1( Description: platelet/endothelial cell adhesion molecule (CD31 antigen). )
Synonyms CD31; CD31 antigen; EndoCAM; GPIIA'; PECAM-1
GO annotations GO_component: integral to membrane; intercellular junction; plasma membrane [PMID 1690453]
GO_function:protein binding
GO_process: cell adhesion; cell motility; cell recognition [PMID 1690453]; signal transduction [PMID 7994021]
RefSeq accession NP_000433
SwissProt accession P16284
GO Pathway:
GO:0007155     cell adhesion
Sequence:(RefSeq accession:NP_000433; substrate region highlighted if known)
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MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD
VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT
AEYQVLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE
KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI
SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG
NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ
KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE
VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN
CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK
EGKPFYQMTS NATQAFWTKQ KANKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK
KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN
SHYGHNDDVG NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDLGKKDTE TVYSEVRKAV
PDAVESRYSR TEGSLDGT
Records:
Category Evidence Reference
A Mutagenesis Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD., Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31, [10350061]
End of Record Details