ul_3419----

Record details:

PPBD protein

Gene name	INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms	MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN
GO annotations	GO_component: GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125] GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession	NP_005532
SwissProt accession	Q13544

Substrate protein

Gene name	FCGR2B
Synonyms	CD32 antigen; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; IgG Fc receptor II-b
GO annotations	GO_component: integral to membrane; plasma membrane [PMID 2139735] GO_function:IgG binding; protein binding [PMID 11567028]; receptor activity GO_process: immune response [PMID 2142460]; signal transduction [PMID 2142460]
RefSeq accession	NP_003992
SwissProt accession	P31994

GO Pathway:

GO:0006470 protein amino acid dephosphorylation

Sequence:(RefSeq accession:NP_003992; substrate region highlighted if known)

1
61
121
181
241
301

MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
LEEPDDQNRI

Records:

Category	Evidence	Reference
A	Peptide library	Koncz G, Pecht I, Gergely J, Sarmay G., Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase, [10382761]

End of Record Details