ul_3436----
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PPBD protein
Gene name INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN
GO annotations GO_component:
GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125]
GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession NP_005532
SwissProt accession Q13544
Substrate protein
Gene name TNFRSF1A( Description: tumor necrosis factor receptor superfamily, member 1A. )
Synonyms CD120a; CD120a antigen; FPF; MGC19588; TBP1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; p55; p55-R; p60
GO annotations GO_component: extracellular region [PMID 12189246]; integral to plasma membrane [PMID 1698610]; membrane
GO_function:protein binding [PMID 15465831]; receptor activity; tumor necrosis factor receptor activity [PMID 2158863]
GO_process: apoptosis; cytokine and chemokine mediated signaling pathway; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade [PMID 12761501]; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; prostaglandin metabolism; signal transduction
RefSeq accession NP_001056
SwissProt accession P19438
GO Pathway:
GO:0006915     apoptosis
Sequence:(RefSeq accession:NP_001056; substrate region highlighted if known)
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MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT
KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV
SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK
SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT
PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY
AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL
LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR
Records:
Category Evidence Reference
A Peptide library Daigle I, Yousefi S, Colonna M, Green DR, Simon HU., Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils, [11786908]
End of Record Details