ul_3443----

Record details:

PPBD protein

Gene name	INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms	MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN
GO annotations	GO_component: GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125] GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession	NP_005532
SwissProt accession	Q13544

Substrate protein

Gene name	CD84( Description: CD84 molecule. )
Synonyms	CD84 antigen; Cell surface antigen MAX.3; DKFZp781E2378; Hly9-beta; LY9B; Leukocyte differentiation antigen CD84; SLAMF5; Signaling lymphocytic activation molecule 5; hCD84; mCD84
GO annotations	GO_component: integral to plasma membrane [PMID 9310491]; plasma membrane [PMID 9310491] GO_function: GO_process: defense response [PMID 9310491]; homophilic cell adhesion [PMID 7797269]
RefSeq accession	NP_003865
SwissProt accession	Q9UIB8

GO Pathway:

GO:0007242 intracellular signaling cascade

Sequence:(RefSeq accession:NP_003865; substrate region highlighted if known)

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MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK IIAWTSKTSV
AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT
TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI
FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL
SSVFLFRLFK RRQDAASKKT IYTYIMASRN TQPAESRIYD EILQSKVLPS KEEPVNTVYS
EVQFADKMGK ASTQDSKPPG TSSYEIVI

Records:

Category	Evidence	Reference
A	Peptide library	Li C, Iosef C, Jia CY, Han VK, Li SS., Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors, [12458214]

End of Record Details