ul_3473----
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PPBD protein
Gene name ITK( Description: IL2-inducible T-cell kinase. )
Synonyms EC 2.7.10.2; EMT; Kinase EMT; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tyrosine-protein kinase Lyk
GO annotations GO_component:
GO_function:ATP binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity [PMID 8364206]; nucleotide binding; transferase activity; zinc ion binding
GO_process: cellular defense response [PMID 8364206]; intracellular signaling cascade; protein amino acid phosphorylation
RefSeq accession NP_005537
SwissProt accession Q08881
Substrate protein
Gene name CD28( Description: CD28 molecule. )
Synonyms MGC138290; Tp44
GO annotations GO_component: external side of plasma membrane [PMID 11390434]; integral to plasma membrane [PMID 9784967]; membrane; plasma membrane [PMID 11390434]
GO_function:coreceptor activity [PMID 9784967]; identical protein binding [PMID 3159820]
GO_process: cell surface receptor linked signal transduction [PMID 9784967]; cytokine biosynthesis [PMID 8717514]; humoral immune response [PMID 8717514]; immune response; positive regulation of anti-apoptosis [PMID 8717514]; positive regulation of interleukin-2 biosynthesis [PMID 3875683]; positive regulation of mitosis [PMID 3159820]; positive regulation of protein biosynthesis [PMID 12028592]; positive regulation of T cell proliferation [PMID 3159820] [PMID 9784967]; positive regulation of viral genome replication [PMID 7492435]
RefSeq accession NP_006130
SwissProt accession P10747
GO Pathway:
GO:0006955     immune response
Sequence:(RefSeq accession:NP_006130; substrate region highlighted if known)
1
61
121
181
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD
SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP
PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR
SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS
Records:
Category Evidence Reference
A Inference Pages F, Ragueneau M, Klasen S, Battifora M, Couez D, Sweet R, Truneh A, Ward SG, Olive D., Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association, [8621607]
End of Record Details