ul_3544----
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PPBD protein
Gene name JAK2( Description: Janus kinase 2 (a protein tyrosine kinase). )
Synonyms EC 2.7.10.2; JAK-2; Janus kinase 2
GO annotations GO_component: cytoskeleton
GO_function:ATP binding; Janus kinase activity; nucleotide binding; protein-tyrosine kinase activity [PMID 9670957]; receptor binding [PMID 11201744]; SH2 domain binding [PMID 9727029]; transferase activity
GO_process: cell motility [PMID 9670957]; intracellular signaling cascade [PMID 9590174]; JAK-STAT cascade [PMID 9670957]; mesoderm development [PMID 9590174]; protein amino acid phosphorylation [PMID 9670957]; regulation of progression through cell cycle [PMID 10692450]
RefSeq accession NP_004963
SwissProt accession O60674
Substrate protein
Gene name AGTR1
Synonyms AT1; AT1AR; AT1BR
GO annotations GO_component: integral to plasma membrane [PMID 1378723]; plasma membrane [PMID 1378723]
GO_function:angiotensin type II receptor activity [PMID 8135787]; bradykinin receptor activity; C-X-C chemokine receptor activity; receptor activity; rhodopsin-like receptor activity
GO_process: circulation [PMID 8135787]; elevation of cytosolic calcium ion concentration [PMID 1567413]; fluid secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) [PMID 1378723]; signal transduction
RefSeq accession NP_000676
SwissProt accession P30556
GO Pathway:
GO:0007259     JAK-STAT cascade
Sequence:(RefSeq accession:NP_000676; substrate region highlighted if known)
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MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC
AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK
IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE
Records:
Category Evidence Reference
A Mutagenesis Marrero MB, Venema VJ, Ju H, Eaton DC, Venema RC., Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2, [9814969]
End of Record Details