ul_3591----

Record details:

PPBD protein

Gene name	LCK( Description: lymphocyte-specific protein tyrosine kinase. )
Synonyms	EC 2.7.10.2; LSK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase; YT16; p56-LCK; p56lck; pp58lck
GO annotations	GO_component: lipid raft [PMID 12732664]; pericentriolar material [PMID 7513706]; plasma membrane [PMID 15489916] GO_function:ATP binding; ATPase binding [PMID 15671290]; CD4 receptor binding [PMID 7486703]; CD8 receptor binding [PMID 2470098]; glycoprotein binding [PMID 7513706] [PMID 14625311] [PMID 15554700]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7504174]; protein C-terminus binding [PMID 16245368]; protein kinase binding [PMID 8618896]; protein serine/threonine phosphatase activity [PMID 8506364]; protein-tyrosine kinase activity [PMID 214242]; SH2 domain binding [PMID 7852312] [PMID 8794306]; transferase activity GO_process: caspase activation [PMID 16116473]; hemopoiesis [PMID 12884910]; induction of apoptosis [PMID 16116473]; intracellular signaling cascade [PMID 10358157]; positive regulation of T cell activation [PMID 8943371]; positive regulation of T cell receptor signaling pathway [PMID 12614355]; protein amino acid phosphorylation [PMID 3265417]; Ras protein signal transduction [PMID 10799545]; regulation of lymphocyte activation [PMID 7852312]; regulation of progression through cell cycle [PMID 8139546]; release of sequestered calcium ion into cytosol; response to drug [PMID 16116473]; T cell differentiation [PMID 1579166]; zinc ion homeostasis [PMID 11739864]
RefSeq accession	NP_005347
SwissProt accession	P06239

Substrate protein

Gene name	CD5( Description: CD5 molecule. )
Synonyms	LEU1; T1
GO annotations	GO_component: integral to plasma membrane [PMID 1711157]; plasma membrane [PMID 11390434] GO_function:protein binding [PMID 1711157]; scavenger receptor activity GO_process: cell proliferation [PMID 3093892]; cell recognition [PMID 1711157]
RefSeq accession	NP_055022
SwissProt accession	P06127

GO Pathway:

GO:0050862 positive regulation of T cell receptor signaling pathway

Sequence:(RefSeq accession:NP_055022; substrate region highlighted if known)

1
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361
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481

MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC
SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS
RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS
LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ
NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL
CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC
KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP
TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS RLSAYPALEG VLHRSSMQPD
NSSDSDYDLH GAQRL

Records:

Category	Evidence	Reference
A	Inference	Raab M, Yamamoto M, Rudd CE., The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck, [7513045]

End of Record Details