ul_36----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name Zfp36( Description: zinc finger protein 36. )
Synonyms Gos24; Growth factor-inducible nuclear protein NUP475; Nup475; Protein TIS11A; TIS11; TIS11D; TISII; TPA-induced sequence 11; TTP; Tis11; Ttp; Zfp-36; Zinc finger protein 36
GO annotations GO_component: cytoplasm; cytosol; nucleus
GO_function:DNA binding; metal ion binding; mRNA binding; nucleic acid binding; zinc ion binding
GO_process: mRNA catabolism; negative regulation of inflammatory response; negative regulation of myeloid cell differentiation; protein kinase cascade; regulation of mRNA stability; RNA destabilization
RefSeq accession NP_035886
SwissProt accession P22893
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_035886; substrate region highlighted if known)
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MDLSAIYESL QSMSHDLSSD HGGTESLGGL WNINSDSIPS GVTSRLTGRS TSLVEGRSCG
WVPPPPGFAP LAPRPGPELS PSPTSPTATP TTSSRYKTEL CRTYSESGRC RYGAKCQFAH
GLGELRQANR HPKYKTELCH KFYLQGRCPY GSRCHFIHNP TEDLALPGQP HVLRQSISFS
GLPSGRRSSP PPPGFSGPSL SSCSFSPSSS PPPPGDLPLS PSAFSAAPGT PVTRRDPNQA
CCPSCRRSTT PSTIWGPLGG LARSPSAHSL GSDPDDYASS GSSLGGSDSP VFEAGVFGPP
QTPAPPRRLP IFNRISVSE
Records:
Category Evidence Reference
A Mutagenesis Johnson BA, Stehn JR, Yaffe MB, Blackwell TK., Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms., [11886850]
End of Record Details