ul_3629----
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PPBD protein
Gene name LCK( Description: lymphocyte-specific protein tyrosine kinase. )
Synonyms EC 2.7.10.2; LSK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase; YT16; p56-LCK; p56lck; pp58lck
GO annotations GO_component: lipid raft [PMID 12732664]; pericentriolar material [PMID 7513706]; plasma membrane [PMID 15489916]
GO_function:ATP binding; ATPase binding [PMID 15671290]; CD4 receptor binding [PMID 7486703]; CD8 receptor binding [PMID 2470098]; glycoprotein binding [PMID 7513706] [PMID 14625311] [PMID 15554700]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7504174]; protein C-terminus binding [PMID 16245368]; protein kinase binding [PMID 8618896]; protein serine/threonine phosphatase activity [PMID 8506364]; protein-tyrosine kinase activity [PMID 214242]; SH2 domain binding [PMID 7852312] [PMID 8794306]; transferase activity
GO_process: caspase activation [PMID 16116473]; hemopoiesis [PMID 12884910]; induction of apoptosis [PMID 16116473]; intracellular signaling cascade [PMID 10358157]; positive regulation of T cell activation [PMID 8943371]; positive regulation of T cell receptor signaling pathway [PMID 12614355]; protein amino acid phosphorylation [PMID 3265417]; Ras protein signal transduction [PMID 10799545]; regulation of lymphocyte activation [PMID 7852312]; regulation of progression through cell cycle [PMID 8139546]; release of sequestered calcium ion into cytosol; response to drug [PMID 16116473]; T cell differentiation [PMID 1579166]; zinc ion homeostasis [PMID 11739864]
RefSeq accession NP_005347
SwissProt accession P06239
Substrate protein
Gene name CD3G( Description: CD3g molecule, gamma (CD3-TCR complex). )
Synonyms CD3-GAMMA; MGC138597; T3G
GO annotations GO_component: integral to plasma membrane [PMID 9485181]; membrane; T cell receptor complex [PMID 9485181]
GO_function:protein heterodimerization activity [PMID 9485181]; receptor signaling complex scaffold activity [PMID 12794121]; T cell receptor binding [PMID 11186279]; transmembrane receptor activity [PMID 12794121]
GO_process: cell surface receptor linked signal transduction [PMID 12407027]; establishment and/or maintenance of cell polarity [PMID 12407027]; protein complex assembly [PMID 12794121]; protein transport [PMID 12794121]; regulation of apoptosis [PMID 12407027]; T cell activation [PMID 12407027]
RefSeq accession NP_000064
SwissProt accession P09693
Sequence:(RefSeq accession:NP_000064; substrate region highlighted if known)
1
61
121
181
MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK
MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF
AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR
RN
Records:
Category Evidence Reference
A Inference Songyang Z, Carraway KL 3rd, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, et al., Catalytic specificity of protein-tyrosine kinases is critical for selective signalling, [7845468]
End of Record Details