ul_37----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name CHEK1( Description: CHK1 checkpoint homolog (S. pombe). )
Synonyms CHK1
GO annotations GO_component: condensed nuclear chromosome [PMID 9382850]; nucleus
GO_function:ATP binding; nucleotide binding; protein binding [PMID 16330544]; protein serine/threonine kinase activity; transferase activity
GO_process: cell cycle; DNA damage checkpoint [PMID 9278511]; DNA repair; gametogenesis [PMID 9382850]; meiotic recombination [PMID 9278511]; negative regulation of cell proliferation [PMID 9278511]; protein amino acid phosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 9278511]
RefSeq accession NP_001265
SwissProt accession O14757
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_001265; substrate region highlighted if known)
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MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK
MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK
RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA
LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF
SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR
NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK VWLPAT
Records:
Category Evidence Reference
A Inference Tian H, Faje AT, Lee SL, Jorgensen TJ., Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways., [11896572]
End of Record Details