ul_3706----
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PPBD protein
Gene name LCK( Description: lymphocyte-specific protein tyrosine kinase. )
Synonyms EC 2.7.10.2; LSK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase; YT16; p56-LCK; p56lck; pp58lck
GO annotations GO_component: lipid raft [PMID 12732664]; pericentriolar material [PMID 7513706]; plasma membrane [PMID 15489916]
GO_function:ATP binding; ATPase binding [PMID 15671290]; CD4 receptor binding [PMID 7486703]; CD8 receptor binding [PMID 2470098]; glycoprotein binding [PMID 7513706] [PMID 14625311] [PMID 15554700]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7504174]; protein C-terminus binding [PMID 16245368]; protein kinase binding [PMID 8618896]; protein serine/threonine phosphatase activity [PMID 8506364]; protein-tyrosine kinase activity [PMID 214242]; SH2 domain binding [PMID 7852312] [PMID 8794306]; transferase activity
GO_process: caspase activation [PMID 16116473]; hemopoiesis [PMID 12884910]; induction of apoptosis [PMID 16116473]; intracellular signaling cascade [PMID 10358157]; positive regulation of T cell activation [PMID 8943371]; positive regulation of T cell receptor signaling pathway [PMID 12614355]; protein amino acid phosphorylation [PMID 3265417]; Ras protein signal transduction [PMID 10799545]; regulation of lymphocyte activation [PMID 7852312]; regulation of progression through cell cycle [PMID 8139546]; release of sequestered calcium ion into cytosol; response to drug [PMID 16116473]; T cell differentiation [PMID 1579166]; zinc ion homeostasis [PMID 11739864]
RefSeq accession NP_005347
SwissProt accession P06239
Substrate protein
Gene name SH2D2A( Description: SH2 domain protein 2A. )
Synonyms F2771; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein
GO annotations GO_component: cytoplasm [PMID 9468509]; soluble fraction [PMID 9468509]
GO_function:protein binding [PMID 10553045]; SH3/SH2 adaptor activity [PMID 9468509]
GO_process: angiogenesis; cell differentiation; intracellular signaling cascade
RefSeq accession NP_003966
SwissProt accession Q9NP31
Sequence:(RefSeq accession:NP_003966; substrate region highlighted if known)
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MEFPLAQICP QGSHEAPIPT FSTFQITDMT RRSCQNLGYT AASPQAPEAA SSTGNAERAE
EVPGEGSLFL QAETRAWFQK TQAHWLLQHG AAPAWFHGFI TRREAERLLE PKPQGCYLVR
FSESAVTFVL TYRSRTCCRH FLLAQLRDGR HVVLGEDSAH ARLQDLLLHY TAHPLSPYGE
TLTEPLARQT PEPAGLSLRT EESNFGSKSQ DPNPQYSPII KQGQAPVPMQ KEGAGEKEPS
QLLRPKPPIP AKPQLPPEVY TIPVPRHRPA PRPKPSNPIY NEPDEPIAFY AMGRGSPGEA
PSNIYVEVED EGLPATLGHP VLRKSWSRPV PGGQNTGGSQ LHSENSVIGQ GPPLPHQPPP
AWRHTLPHNL SRQVLQDRGQ AWLPLGPPQ
Records:
Category Evidence Reference
A Inference Granum S, Sundvold-Gjerstad V, Dai KZ, Kolltveit KM, Hildebrand K, Huitfeldt HS, Lea T, Spurkland A., Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7, [16839418]
End of Record Details