ul_3758----
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PPBD protein
Gene name LYN( Description: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog. )
Synonyms FLJ26625; JTK8
GO annotations GO_component: cytoplasm; nucleus
GO_function:ATP binding; erythropoietin receptor binding; nucleotide binding; protein binding [PMID 7859737] [PMID 9020138]; receptor signaling protein tyrosine kinase activity [PMID 10748115]; transferase activity
GO_process: erythrocyte differentiation; hemoglobin biosynthesis; intracellular signaling cascade; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation [PMID 3561390]; response to hormone stimulus
RefSeq accession NP_002341
SwissProt accession P07948
Substrate protein
Gene name HCLS1( Description: hematopoietic cell-specific Lyn substrate 1. )
Synonyms CTTNL; HS1; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75
GO annotations GO_component: cytoplasm; DNA-directed RNA polymerase II, core complex [PMID 2587259]; nucleus
GO_function:protein binding; transcription factor activity [PMID 2587259]
GO_process: erythrocyte differentiation; intracellular signaling cascade [PMID 8978766]; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of transcription, DNA-dependent [PMID 2587259]; response to hormone stimulus
RefSeq accession NP_005326
SwissProt accession P14317
GO Pathway:
GO:0006468     protein amio acid phosphorylation
Sequence:(RefSeq accession:NP_005326; substrate region highlighted if known)
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MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA
GAGAGAVALG ISAVALYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN
YVKLLE
Records:
Category Evidence Reference
A Peptide library Donella-Deana A, Cesaro L, Ruzzene M, Brunati AM, Marin O, Pinna LA., Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity, [9477973]
A Inference Brunati AM, Deana R, Folda A, Massimino ML, Marin O, Ledro S, Pinna LA, Donella-Deana A., Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein, [15795233]
End of Record Details