ul_3779----
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PPBD protein
Gene name LYN( Description: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog. )
Synonyms FLJ26625; JTK8
GO annotations GO_component: cytoplasm; nucleus
GO_function:ATP binding; erythropoietin receptor binding; nucleotide binding; protein binding [PMID 7859737] [PMID 9020138]; receptor signaling protein tyrosine kinase activity [PMID 10748115]; transferase activity
GO_process: erythrocyte differentiation; hemoglobin biosynthesis; intracellular signaling cascade; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation [PMID 3561390]; response to hormone stimulus
RefSeq accession NP_002341
SwissProt accession P07948
Substrate protein
Gene name Ptk2( Description: PTK2 protein tyrosine kinase 2. )
Synonyms FAK; FRNK; Fadk; KIAA4203; mKIAA4203
GO annotations GO_component: apical plasma membrane; cytoskeleton; focal adhesion; lamellipodium
GO_function:ATP binding; binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity
GO_process: blood vessel development; cell motility; establishment of nucleus localization; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; microtubule cytoskeleton organization and biogenesis; negative regulation of organ size; neuron migration; protein amino acid phosphorylation
RefSeq accession NP_032008
SwissProt accession
Sequence:(RefSeq accession:NP_032008; substrate region highlighted if known)
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MAAAYLDPNL NHTPSSSTKT HLGTGMERSP GAMERVLKVF HHFESSSEPT TWASIIRHGD
ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW
KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMQEIA DQVDQEIALK LGCLEIRRSY
WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI
LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFNQVQ
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGATQSFII
RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE
RIELGRCIGE GQFGDVHQGV YLSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH
PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK
RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA
YDPSRRPRFT ELKAQLSTIL EEEKVQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY
PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGIPAMAGSI YQGQASLLDQ TELWNHRPQE
MSMWQPSVED SAALDLRGMG QVLPPHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS
RGSIDREDGS FQGPTGNQHI YQPVGKPDPA APPKKPPRPG APGHLSNLSS ISSPADSYNE
GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY VPMVKEVGLA
LRTLLATVDE TIPALPASTH REIEMAQKLL NSDLGELISK MKLAQQYVMT SLQQEYKKQM
LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR PH
Records:
Category Evidence Reference
A Inference Mlinaric-Rascan I, Yamamoto T., B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM, [11389892]
End of Record Details