ul_3795----
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PPBD protein
Gene name MATK
Synonyms EC 2.7.10.2; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK
GO annotations GO_component: soluble fraction
GO_function:ATP binding; nucleotide binding; protein binding [PMID 8999872]; protein-tyrosine kinase activity [PMID 7530249]; transferase activity
GO_process: cell proliferation [PMID 8288563]; intracellular signaling cascade; mesoderm development [PMID 8288563]; positive regulation of cell proliferation [PMID 8999872]; protein amino acid phosphorylation [PMID 7530249]; regulation of progression through cell cycle [PMID 7530249]
RefSeq accession NP_002369
SwissProt accession P42679
Substrate protein
Gene name KIT( Description: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. )
Synonyms C-Kit; CD117; CD117 antigen; EC 2.7.10.1; PBT; Proto-oncogene tyrosine-protein kinase Kit; SCFR; c-kit
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; receptor activity; receptor signaling protein tyrosine kinase activity [PMID 9438854]; transferase activity; vascular endothelial growth factor receptor activity
GO_process: protein amino acid dephosphorylation; protein amino acid phosphorylation; signal transduction [PMID 9990072]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_000213
SwissProt accession P10721
Sequence:(RefSeq accession:NP_000213; substrate region highlighted if known)
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MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PGKSDLIVRV GDEIRLLCTD
PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK HGLSNSIYVF VRDPAKLFLV
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPLPKDL RFIPDPKAGI MIKSVKRAYH
RLCLHCSVDQ EGKSVLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS
SVYSTWKREN SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY MNRTFTDKWE
DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN AAIAFNVYVN TKPEILTYDR
LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC SASVLPVDVQ TLNSSGPPFG KLVVQSSIDS
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKG NNKEQIHPHT LFTPLLIGFV IVAGMMCIIV
MILTYKYLQK PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF
GKVVEATAYG LIKSDAAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH MNIVNLLGAC
TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAEA ALYKNLLHSK ESSCSDSTNE
YMDMKPGVSY VVPTKADKRR SVRIGSYIER DVTPAIMEDD ELALDLEDLL SFSYQVAKGM
AFLASKNCIH RDLAARNILL THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES
IFNCVYTFES DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLA NCSPNRQKPV VDHSVRINSV
GSTASSSQPL LVHDDV
Records:
Category Evidence Reference
A Peptide library Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H., Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes, [9038210]
End of Record Details