ul_3825----
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PPBD protein
Gene name NCK1( Description: NCK adaptor protein 1. )
Synonyms MGC12668; NCK; NCK adaptor protein 1; NCKalpha; SH2/SH3 adaptor protein NCK-alpha
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; receptor binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_006144
SwissProt accession P16333
Substrate protein
Gene name IRS1( Description: insulin receptor substrate 1. )
Synonyms HIRS-1
GO annotations GO_component: cytoplasm; microsome; nucleus
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phosphoinositide 3-kinase binding [PMID 16043515]; protein binding [PMID 8388384] [PMID 11018022]; SH2 domain binding; signal transducer activity [PMID 1311924] [PMID 8513971]; transmembrane receptor protein tyrosine kinase docking protein activity [PMID 1648180]
GO_process: insulin receptor signaling pathway [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; signal transduction [PMID 1311924]
RefSeq accession NP_005535
SwissProt accession P35568
Sequence:(RefSeq accession:NP_005535; substrate region highlighted if known)
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961
1021
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1141
1201
MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH
HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI
GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV
DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT
RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR
GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP
SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN
GHYILSRGGN GHRCTPGTGL GTSPALAGDE AASAADLDNR FRKRTHSAGT SPTITHQKTP
SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR
PDSSTLHTDD GYMPMSPGVA PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN
GYMMMSPSGG CSPDIGGGPS SSSSSSNAVP SGTSYGKLWT NGVGGHHSHV LPHPKPPVES
SGGKLLPCTG DYMNMSPVGD SNTSSPSDCY YGPEDPQHKP VLSYYSLPRS FKHTQRPGEP
EEGARHQHLR LSTSSGRLLY AATADDSSSS TSSDSLGGGY CGARLEPSLP HPHHQVLQPH
LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQQQ QQPLLHPPEP KSPGEYVNIE
FGSDQSGYLS GPVAFHSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR RAAWQESTGV
EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPAAPV SYADMRTGIA
AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS AFTRVNLSPN
RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAVGGGGG SSSSSEDVKR
HSSASFENVW LRPGELGGAP KEPAKLCGAA GGLENGLNYI DLDLVKDFKQ CPQECTPEPQ
PPPPPPPHQP LGSGESSSTR RSSEDLSAYA SISFQKQPED RQ
Records:
Category Evidence Reference
A Inference Wang L, Hayashi H, Mitani Y, Ishii K, Ohnishi T, Niwa Y, Kido H, Ebina Y., Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells, [7488107]
End of Record Details