ul_3880----
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PPBD protein
Gene name NCK1( Description: NCK adaptor protein 1. )
Synonyms MGC12668; NCK; NCK adaptor protein 1; NCKalpha; SH2/SH3 adaptor protein NCK-alpha
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; receptor binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_006144
SwissProt accession P16333
Substrate protein
Gene name Dok2( Description: docking protein 2. )
Synonyms DokR; Frip
GO annotations GO_component: cellular_component
GO_function:insulin receptor binding; kinase activity; transmembrane receptor protein tyrosine kinase docking protein activity; transmembrane receptor protein tyrosine kinase signaling protein activity
GO_process: MAPKKK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_034201
SwissProt accession
Sequence:(RefSeq accession:NP_034201; substrate region highlighted if known)
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MVRMEEPAVK QGFLHLQQQQ TFGKKWRRFA AVLYGESGCA LARLELQDVP EKTRRGEATR
KVVRLSDCLR VAEVGSEASS PRDTSAFILE TKERLYLLAA PSAERSDWIQ AICLLAFPGQ
RKGSPGLEEK SGSPCMEENE LYSSSTTGLC KEYMVTIRPT EASERCRLRG SYTLRTGVSA
LELWGGPEPG TQLYDWPYRF LRRFGRDKAT FSFEAGRRCL SGEGNFEFET RHGNEIFQAL
EKVIAVQKNA TPSGPPSLPA TGPMMPTVLP RPESPYSRPH DSLPSPSPGT LVPGMRPGAP
EGEYAVPFDT VAHSLRKSFR GLLTGPPPHL PDPLYDSIQE DPGAPLPDHI YDEPEGVAAL
SLYDRTQRPS GETWREQATA DGGPSSLQQD SSVPDWPQAT EYDNVILKKG PK
Records:
Category Evidence Reference
A Mutagenesis Lock P, Casagranda F, Dunn AR., Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck, [10428862]
End of Record Details