ul_3901----
Record details: Hide
PPBD protein
Gene name NCK1( Description: NCK adaptor protein 1. )
Synonyms MGC12668; NCK; NCK adaptor protein 1; NCKalpha; SH2/SH3 adaptor protein NCK-alpha
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; receptor binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_006144
SwissProt accession P16333
Substrate protein
Gene name Tir( Description: Tir. )
Synonyms
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_312588
SwissProt accession
GO Pathway:
KEGG:05130     Pathogenic Escherichia coli infection - EHEC
Sequence:(RefSeq accession:NP_312588; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
MPIGNLGHNP NVNNSIPPAP PLPSQTDGAG GRGQLINSTG PLGSRALFTP VRNSMADSGD
NRASDVPGLP VNPMRLAASE ITLNDGFEVL HDHGPLDTLN RQIGSSVFRV ETQEDGKHIA
VGQRNGVETS VVLSDQEYAR LQSIDPEGKD KFVFTGGRGG AGHAMVTVAS DITEARQRIL
ELLEPKGTGE SKGAGESKGV GELRESNSGA ENTTETQTST STSSLRSDPK LWLALGTVAT
GLIGLAATGI VQALALTPEP DSPTTTDPDA AASATETATR DQLTKEAFQN PDNQKVNIDE
LGNAIPSGVL KDDVVANIEE QAKAAGEEAK QQAIENNAQA QKKYDEQQAK RQEELKVSSG
AGYGLSGALI LGGGIGVAVT AALHRKNQPV EQTTTTTTTT TTTSARTVEN KPANNTPAQG
NVDTPGSEDT MESRRSSMAS TSSTFFDTSS IGTVQNPYAD VKTSLHDSQV PTSNSNTSVQ
NMGNTDSVVY STIQHPPRDT TDNGARLLGN PSAGIQSTYA RLALSGGLRH DMGGLTGGSN
SAVNTSNNPP APGSHRFV
Records:
Category Evidence Reference
A Mutagenesis Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish GD, Pawson T, Finlay BB., Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells, [11533668]
End of Record Details