ul_3907----
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PPBD protein
Gene name NCK1( Description: NCK adaptor protein 1. )
Synonyms MGC12668; NCK; NCK adaptor protein 1; NCKalpha; SH2/SH3 adaptor protein NCK-alpha
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; receptor binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_006144
SwissProt accession P16333
Substrate protein
Gene name Ntrk2( Description: neurotrophic tyrosine kinase, receptor, type 2. )
Synonyms RATTRKB1; TRKB1; Tkrb
GO annotations GO_component: cytosol; integral to membrane; integral to plasma membrane; plasma membrane
GO_function:neurotrophin binding; nucleotide binding; protein binding; receptor activity; transferase activity
GO_process: cell differentiation; feeding behavior; mechanoreceptor differentiation; nervous system development; regulation of metabolism; retinal rod cell development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
RefSeq accession NP_036863
SwissProt accession
Sequence:(RefSeq accession:NP_036863; substrate region highlighted if known)
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MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP GIVAFPRLEP
NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD SGLKFVAYKA FLKNGNLRHI
NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES
SKNTPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD
VADQTNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGPASVI SNDDDSASPL
HHISNGSNTP SSSEGGPDAV IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK
RELGEGAFGK VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS QMLHIAQQIA
AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV YSTDYYRVGG HTMLPIRWMP
PESIMYRKFT TESDVWSLGV VLWEIFTYGK QPWYQLSNNE VIECITQGRV LQRPRTCPQE
VYELMLGCWQ REPHTRKNIK NIHTLLQNLA KASPVYLDIL G
Records:
Category Evidence Reference
A Mutagenesis Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S., Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor, [12074588]
End of Record Details