ul_3929----
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PPBD protein
Gene name NCK2
Synonyms NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; protein binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; negative regulation of cell proliferation [PMID 9737977]; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; regulation of epidermal growth factor receptor activity [PMID 9737977]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_003572
SwissProt accession O43639
Substrate protein
Gene name PDGFRB( Description: platelet-derived growth factor receptor, beta polypeptide. )
Synonyms CD140B; CD140b antigen; EC 2.7.10.1; JTK12; PDGF-R-beta; PDGFR; PDGFR1
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; platelet activating factor receptor activity [PMID 2536956]; platelet-derived growth factor receptor activity [PMID 2536956]; protein binding [PMID 2157284]; receptor activity; transferase activity; vascular endothelial growth factor receptor activity
GO_process: protein amino acid phosphorylation; signal transduction [PMID 2536956] [PMID 10821867]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_002600
SwissProt accession P09619
GO Pathway:
GO:0007165     signal transduction
Sequence:(RefSeq accession:NP_002600; substrate region highlighted if known)
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MRLPGAMPAL ALKGELLLLS LLLLLEPQIS QGLVVTPPGP ELVLNVSSTF VLTCSGSAPV
VWERMSQEPP QEMAKAQDGT FSSVLTLTNL TGLDTGEYFC THNDSRGLET DERKRLYIFV
PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDVALP VPYDHQRGFS
GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN
EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH
QDEKAINITV VESGYVRLLG EVGTLQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS
SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL
ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPTLLGNSS EEESQLETNV
TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDTQE VIVVPHSLPF KVVVISAILA
LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL
PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP
SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG
GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER
LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDTSSVLYT AVQPNEGDND
YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQDEP EPEPQLELQV
EPEPELEQLP DSGCPAPRAE AEDSFL
Records:
Category Evidence Reference
A Mutagenesis Chen M, She H, Kim A, Woodley DT, Li W., Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb, [11027258]
End of Record Details