ul_3930----
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PPBD protein
Gene name NCK2
Synonyms NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; protein binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; negative regulation of cell proliferation [PMID 9737977]; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; regulation of epidermal growth factor receptor activity [PMID 9737977]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_003572
SwissProt accession O43639
Substrate protein
Gene name EFNB1( Description: ephrin-B1. )
Synonyms CFND; CFNS; EFL3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; EPLG2; Elk-L; LERK-2; LERK2; MGC8782
GO annotations GO_component: integral to plasma membrane [PMID 8660976]; membrane; soluble fraction [PMID 8798744]; synapse
GO_function:ephrin receptor binding [PMID 8798744]; protein binding [PMID 9883737]
GO_process: cell adhesion [PMID 8798744]; cell differentiation; cell-cell signaling [PMID 8798744]; nervous system development
RefSeq accession NP_004420
SwissProt accession P98172
GO Pathway:
GO:0007155     cell adhesion
Sequence:(RefSeq accession:NP_004420; substrate region highlighted if known)
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MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL
DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN
YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR
PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL
FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS
DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV
Records:
Category Evidence Reference
A Inference Cowan CA, Henkemeyer M., The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals, [11557983]
End of Record Details