ul_3933----
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PPBD protein
Gene name NCK2
Synonyms NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; protein binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; negative regulation of cell proliferation [PMID 9737977]; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; regulation of epidermal growth factor receptor activity [PMID 9737977]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_003572
SwissProt accession O43639
Substrate protein
Gene name EFNB2( Description: ephrin-B2. )
Synonyms EPH-related receptor tyrosine kinase ligand 5; EPLG5; HTK ligand; HTK-L; HTKL; Htk-L; LERK-5; LERK5; MGC126226; MGC126227; MGC126228
GO annotations GO_component: integral to plasma membrane [PMID 8660976]; membrane; plasma membrane [PMID 8660976]
GO_function:ephrin receptor binding [PMID 8559144]
GO_process: cell differentiation; cell-cell signaling [PMID 8559144]; morphogenesis [PMID 9630219]; nervous system development
RefSeq accession NP_004084
SwissProt accession P52799
GO Pathway:
GO:0007155     cell adhesion
GO:0007267     cell-cell signaling
Sequence:(RefSeq accession:NP_004084; substrate region highlighted if known)
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MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI
ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN
LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT
RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV
IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF
CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV
Records:
Category Evidence Reference
A Inference Cowan CA, Henkemeyer M., The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals, [11557983]
A Peptide affinity isolation Song J., Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties, [12606549]
A Structure Ran X, Song J., Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain, [15764601]
End of Record Details