ul_3958----
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PPBD protein
Gene name NCK2
Synonyms NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
GO annotations GO_component: cytoplasm [PMID 12110186]
GO_function:cytoskeletal adaptor activity [PMID 12110186]; protein binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 12110186]
GO_process: intracellular signaling cascade; negative regulation of cell proliferation [PMID 9737977]; positive regulation of actin filament polymerization [PMID 12110186]; positive regulation of T cell proliferation [PMID 12110186]; regulation of epidermal growth factor receptor activity [PMID 9737977]; signal complex formation [PMID 12110186]; T cell activation [PMID 12110186]
RefSeq accession NP_003572
SwissProt accession O43639
Substrate protein
Gene name DDR1( Description: discoidin domain receptor family, member 1. )
Synonyms C; CAK; CD167; Cell adhesion kinase; DDR; Discoidin receptor tyrosine kinase; EC 2.7.10.1; EDDR1; Epithelial discoidin domain receptor 1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; Protein-tyrosine kinase RTK 6; RTK6; TRK E; TRKE; Tyrosine kinase DDR; Tyrosine-protein kinase CAK
GO annotations GO_component: integral to plasma membrane [PMID 8390675]; membrane
GO_function:ATP binding; nucleotide binding; protein-tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity [PMID 9659899]
GO_process: cell adhesion [PMID 8302582]; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_054700
SwissProt accession Q08345
Sequence:(RefSeq accession:NP_054700; substrate region highlighted if known)
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MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI
GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE
PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT
QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP
PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD
ATKNASFSLF SRNDFLKEVK IMSRLKDPNI IRLLGVCVQD DPLCMITDYM ENGDLNQFLS
AHQLEDKAAE GAPGDGQAAQ GPTISYPMLL HVAAQIASGM RYLATLNFVH RDLATRNCLV
GENFTIKIAD FGMSRNLYAG DYYRVQGRAV LPIRWMAWEC ILMGKFTTAS DVWAFGVTLW
EVLMLCRAQP FGQLTDEQVI ENAGEFFRDQ GRQVYLSRPP ACPQGLYELM LRCWSRESEQ
RPPFSQLHRF LAEDALNTV
Records:
Category Evidence Reference
A Inference Koo DH, McFadden C, Huang Y, Abdulhussein R, Friese-Hamim M, Vogel WF., Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1, [16337946]
End of Record Details